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迟发性综合征中抗胆碱能药物的处方:精神科医生的“双中心”调查

Prescription of Anticholinergics in Tardive Syndromes: A "Dual Center" Survey among Psychiatrists.

作者信息

Cutino Anna, Bhidayasiri Roongroj, Colosimo Carlo

机构信息

Department of Neurology, Santa Maria University Hospital, Terni, Italy.

Chulalongkorn Centre of Excellence for Parkinson's Disease & Related Disorders, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.

出版信息

Parkinsons Dis. 2020 Nov 22;2020:8870945. doi: 10.1155/2020/8870945. eCollection 2020.

Abstract

METHODS

We assessed the attitude of two groups of psychiatrists (practicing in Italy and Thailand) towards the prescription of anticholinergics by a short online survey consisting of four questions. A total of one hundred questionnaires were sent out (50 in Italy and 50 in Thailand), and 42 psychiatrists responded to the survey.

RESULTS

When comparing the two cohorts, the difference, both for age and years of practice, was statistically significant ( < 0.00001 and < 0.0001, respectively), with Thai psychiatrists being younger and with less time in practice as specialists. The results from the survey showed that the prescription of anticholinergic drugs at the beginning of the antipsychotic treatment was used by 5 psychiatrists (20.0%) of the Italian cohort and by 1 (5.9%) of the Thai cohort. Regarding the Italian psychiatrists who did not prescribe anticholinergics concomitantly with neuroleptics, we found that 5 (25.0%) of them had prescribed anticholinergics in the past but had abandoned this practice, while 15 (93.7%) of the Thai psychiatrists who did not prescribe anticholinergics at the moment of the survey answered that they had prescribed these drugs in the past.

CONCLUSION

According to this preliminary survey, the practice to use anticholinergics as a treatment for tardive syndromes is still relatively common, particularly in psychiatrists of the older generation, but seemingly in decline over the years.

摘要

方法

我们通过一项包含四个问题的简短在线调查,评估了两组精神科医生(分别在意大利和泰国执业)对抗胆碱能药物处方的态度。总共发放了100份问卷(意大利50份,泰国50份),42位精神科医生回复了调查。

结果

比较两组人群时,年龄和执业年限的差异均具有统计学意义(分别为<0.00001和<0.0001),泰国精神科医生更年轻,作为专科医生的执业时间更短。调查结果显示,意大利组中有5位精神科医生(20.0%)在抗精神病治疗开始时使用抗胆碱能药物,泰国组中有1位(5.9%)使用。对于未同时开具抗胆碱能药物与抗精神病药物的意大利精神科医生,我们发现其中5位(25.0%)过去曾开具抗胆碱能药物,但已放弃这种做法,而在调查时未开具抗胆碱能药物的泰国精神科医生中,15位(93.7%)回答他们过去曾开具过这些药物。

结论

根据这项初步调查,使用抗胆碱能药物治疗迟发性综合征的做法仍然相对普遍,尤其是在老一辈精神科医生中,但近年来似乎在减少。

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