Deruyttere M, Lepoutre L, Heylen H, Samain H, Pennoit H
Medical Center for General Practitioners, Heverlee, Belgium.
Clin Ther. 1987;10(1):44-51.
The effects of cisapride, a nondopaminolytic motility-enhancing agent, were studied in 56 patients with chronic functional dyspepsia; all had symptoms suggestive of delayed gastric emptying. The patients received 4 mg or 8 mg of cisapride or placebo orally three times daily for two successive three-week periods according to a randomized, double-blind, crossover study design. Although there was a high placebo response (55% showed good or excellent results), the global response to treatment was significantly (P = 0.024) in favor of cisapride (75% had good or excellent results). The drug was particularly superior to placebo (P = 0.03) in the improvement of a cluster of symptoms typical of postprandial discomfort, including early satiety and nausea. Side effects were minimal.
研究了西沙必利（一种非多巴胺能促动力剂）对56例慢性功能性消化不良患者的影响；所有患者均有提示胃排空延迟的症状。根据随机、双盲、交叉研究设计，患者连续两个为期三周的时间段内，每日口服3次4毫克或8毫克西沙必利或安慰剂。尽管安慰剂反应率较高（55%显示良好或优异结果），但总体治疗反应显著（P = 0.024）有利于西沙必利（75%有良好或优异结果）。该药物在改善包括早饱感和恶心在内的一系列典型餐后不适症状方面尤其优于安慰剂（P = 0.03）。副作用极小。
