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神经科医生的临床神经肿瘤学

Clinical neuro-oncology for the neurologist.

作者信息

Lukas Rimas V, Taylor Jennie W, Kurz Sylvia C, Mohile Nimish A

机构信息

Department of Neurology (RVL), Northwestern University, Chicago, IL; The Lou & Jean Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center (RVL), Chicago, IL; Departments of Neurology and Neurological Surgery (JWT), University of California-San Francisco; Department of Neurology (SCK), New York University, New York; Brain and Spine Tumor Center at the Perlmutter Cancer Center (SCK), New York, NY; and Department of Neurology (NAM), University of Rochester, NY.

出版信息

Neurol Clin Pract. 2020 Oct;10(5):458-465. doi: 10.1212/CPJ.0000000000000765.

DOI:10.1212/CPJ.0000000000000765
PMID:33299675
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7717629/
Abstract

PURPOSE OF REVIEW

Neuro-oncologic patients are routinely encountered in clinical practice. Neuro-oncology is a rapidly evolving field, so understanding the most classic paradigms and contemporary advances will optimize patient care.

RECENT FINDINGS

We discuss the recent reclassification of tumors via molecular characteristics as it applies to direct clinical practice and review the contemporary standard of care for infiltrating gliomas, meningiomas, brain metastases, and CNS lymphoma.

SUMMARY

We provide a straightforward primer on neuro-oncology with a focus on the brain tumors most commonly encountered by the adult neurologist and a clear emphasis on clinically relevant points including those which have recently become incorporated into our standard management. We cite key reviews to allow interested readers an opportunity to gain a more comprehensive understanding of specific topics.

摘要

综述目的

神经肿瘤患者在临床实践中很常见。神经肿瘤学是一个快速发展的领域,因此了解最经典的模式和当代进展将优化患者护理。

最新发现

我们讨论了基于分子特征的肿瘤重新分类在直接临床实践中的应用,并回顾了浸润性胶质瘤、脑膜瘤、脑转移瘤和中枢神经系统淋巴瘤的当代护理标准。

总结

我们提供了一份关于神经肿瘤学的简明入门指南,重点关注成年神经科医生最常遇到的脑肿瘤,并明确强调临床相关要点,包括那些最近已纳入我们标准治疗的要点。我们引用关键综述,以便有兴趣的读者有机会更全面地了解特定主题。

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Clinical neuro-oncology for the neurologist.神经科医生的临床神经肿瘤学
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本文引用的文献

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Pivotal therapeutic trials for infiltrating gliomas and how they affect clinical practice.浸润性胶质瘤的关键治疗试验及其对临床实践的影响。
Neurooncol Pract. 2017 Dec;4(4):209-219. doi: 10.1093/nop/npw016. Epub 2016 Aug 26.
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The medical necessity of advanced molecular testing in the diagnosis and treatment of brain tumor patients.高级分子检测在脑肿瘤患者诊断和治疗中的医学必要性。
Neuro Oncol. 2019 Dec 17;21(12):1498-1508. doi: 10.1093/neuonc/noz119.
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Genetic and molecular epidemiology of adult diffuse glioma.成人弥漫性神经胶质瘤的遗传和分子流行病学。
Nat Rev Neurol. 2019 Jul;15(7):405-417. doi: 10.1038/s41582-019-0220-2. Epub 2019 Jun 21.
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Newly Diagnosed Glioblastoma: A Review on Clinical Management.新诊断的胶质母细胞瘤:临床管理综述。
Oncology (Williston Park). 2019 Mar 13;33(3):91-100.
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Glioblastoma in Elderly Patients: Current Management and Future Perspectives.老年患者的胶质母细胞瘤:当前治疗与未来展望
Cancers (Basel). 2019 Mar 8;11(3):336. doi: 10.3390/cancers11030336.
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Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter (CeTeG/NOA-09): a randomised, open-label, phase 3 trial.洛莫司汀-替莫唑胺联合治疗与标准替莫唑胺治疗在甲基化 MGMT 启动子的新诊断胶质母细胞瘤患者中的比较(CeTeG/NOA-09):一项随机、开放标签、3 期试验。
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Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma.抗 PD-1 免疫疗法治疗胶质母细胞瘤的免疫和基因组相关性。
Nat Med. 2019 Mar;25(3):462-469. doi: 10.1038/s41591-019-0349-y. Epub 2019 Feb 11.
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Molecular and translational advances in meningiomas.脑膜瘤的分子和转化进展。
Neuro Oncol. 2019 Jan 14;21(Suppl 1):i4-i17. doi: 10.1093/neuonc/noy178.
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Recent advances in managing brain metastasis.脑转移瘤治疗的最新进展。
F1000Res. 2018 Nov 9;7. doi: 10.12688/f1000research.15903.1. eCollection 2018.