与感染相关的前列腺增生腺体内浸润的调节性T细胞和辅助性T细胞17
Infiltrating Treg and Th17 Cells of the Prostate Hypertrophy Gland Associated with Infection.
作者信息
Radej Sebastian, Płaza Paweł, Olender Alina, Szewc Monika, Bar Krzysztof, Maciejewski Ryszard
机构信息
Department of Normal Anatomy, Medical University of Lublin, Lublin, Poland.
Urology and Urological Oncology, Medical University of Lublin, Lublin, Poland.
出版信息
Res Rep Urol. 2020 Nov 30;12:593-597. doi: 10.2147/RRU.S284066. eCollection 2020.
PURPOSE
The aim of the study was to evaluate prostate cell infiltration by CD4(+)IL-17(+) and Treg cells in BPH and PCa patients depending on infection in the prostate gland.
PATIENTS AND METHODS
Prostate fragments were collected from 54 patients with PCa and 34 patients with BPH. Rapid ID 32 was used to identify the bacteria. Cells were analyzed by flow cytometry BD FACSCanto II. Statistical analysis was performed using Statistica 7 software (TIBCO Software Inc, USA).
RESULTS
was detected in 35% of patients with PCa and 41% of individuals with BPH. The infiltration of CD4(+)IL-17(+) and Treg cells was statistically significantly higher ( = 0.001) in patients with BPH and positive for . A statistically considerably higher ( = 0.001) infiltration of Treg cells in treated for PCa with infection was also demonstrated.
CONCLUSION
Prostatitis caused by may contribute to the development of BPH and PCa.
目的
本研究旨在根据前列腺感染情况评估良性前列腺增生（BPH）和前列腺癌（PCa）患者中CD4(+)IL-17(+)细胞和调节性T细胞（Treg）对前列腺细胞的浸润情况。
患者与方法
收集了54例前列腺癌患者和34例良性前列腺增生患者的前列腺组织碎片。采用快速ID 32鉴定细菌。通过流式细胞仪BD FACSCanto II分析细胞。使用Statistica 7软件（美国TIBCO软件公司）进行统计分析。
结果
在35%的前列腺癌患者和41%的良性前列腺增生患者中检测到（某种细菌，原文未明确）。在良性前列腺增生且（某种细菌检测）呈阳性的患者中，CD4(+)IL-17(+)细胞和Treg细胞的浸润在统计学上显著更高（P = 0.001）。在因（某种细菌）感染接受治疗的前列腺癌患者中，Treg细胞的浸润在统计学上也显著更高（P = 0.001）。
结论
由（某种细菌）引起的前列腺炎可能有助于良性前列腺增生和前列腺癌的发展。
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