Prasad Shashanka K, Bhat Smitha, Shashank Dharini, C R Akshatha, R Sindhu, Rachtanapun Pornchai, Devegowda Devananda, Santhekadur Prasanna K, Sommano Sarana Rose
Department of Biotechnology and Bioinformatics, Faculty of Life Sciences, Jagadguru Sri Shivarathreeshwara (JSS) Academy of Higher Education and Research (JSSAHER), Mysuru, India.
Department of General Surgery, Adichunchanagiri Institute of Medical Sciences, Mandya, India.
Front Oncol. 2022 Apr 4;12:836004. doi: 10.3389/fonc.2022.836004. eCollection 2022.
Cancers are known to have multifactorial etiology. Certain bacteria and viruses are proven carcinogens. Lately, there has been in-depth research investigating carcinogenic capabilities of some bacteria. Reports indicate that chronic inflammation and harmful bacterial metabolites to be strong promoters of neoplasticity. -induced gastric adenocarcinoma is the best illustration of the chronic inflammation paradigm of oncogenesis. Chronic inflammation, which produces excessive reactive oxygen species (ROS) is hypothesized to cause cancerous cell proliferation. Other possible bacteria-dependent mechanisms and virulence factors have also been suspected of playing a vital role in the bacteria-induced-cancer(s). Numerous attempts have been made to explore and establish the possible relationship between the two. With the growing concerns on anti-microbial resistance and over-dependence of mankind on antibiotics to treat bacterial infections, it must be deemed critical to understand and identify carcinogenic bacteria, to establish their role in causing cancer.
已知癌症具有多因素病因。某些细菌和病毒被证实是致癌物。最近，对一些细菌的致癌能力进行了深入研究。报告表明，慢性炎症和有害细菌代谢产物是肿瘤发生的强力促进因素。幽门螺杆菌诱导的胃腺癌是肿瘤发生慢性炎症范式的最佳例证。产生过量活性氧（ROS）的慢性炎症被认为会导致癌细胞增殖。其他可能的细菌依赖性机制和毒力因子也被怀疑在细菌诱导的癌症中起重要作用。人们已经进行了许多尝试来探索和建立两者之间的可能关系。随着对抗菌素耐药性的日益关注以及人类过度依赖抗生素治疗细菌感染，了解和识别致癌细菌、确定它们在致癌中的作用必定至关重要。
