Helbert Hugo, Antunes Ines Farinha, Luurtsema Gert, Szymanski Wiktor, Feringa Ben L, Elsinga Philip H
Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
Chem Commun (Camb). 2021 Jan 7;57(2):203-206. doi: 10.1039/d0cc05392a. Epub 2020 Dec 10.
The cross-coupling of aryl bromides with [C]CHLi for the labelling of a variety of tracers for positron emission tomography (PET) is presented. The radiolabelled products were obtained in excellent yields, at rt and after short reaction times (3-5 min) compatible with the half-life of C (20.4 min). The automation of the protocol on a synthesis module is investigated, representing an important step towards a fast method for the synthesis of C-labelled compounds for PET imaging.
本文介绍了芳基溴化物与[C]CHLi的交叉偶联反应，用于标记多种正电子发射断层扫描（PET）示踪剂。放射性标记产物以优异的产率获得，反应在室温下进行，且反应时间短（3 - 5分钟），这与C的半衰期（20.4分钟）相兼容。研究了该方案在合成模块上的自动化，这是朝着快速合成用于PET成像的C标记化合物方法迈出的重要一步。
