钯催化的（三甲基硅基）甲基锂与（杂）芳基卤化物的 C(sp(3))-C(sp(2)) 交叉偶联反应。
Palladium-Catalyzed C(sp(3))-C(sp(2)) Cross-Coupling of (Trimethylsilyl)methyllithium with (Hetero)Aryl Halides.
机构信息
Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
出版信息
Org Lett. 2015 May 1;17(9):2262-5. doi: 10.1021/acs.orglett.5b00905. Epub 2015 Apr 14.
PMID:25871302
Abstract
The palladium-catalyzed direct cross-coupling of a range of organic chlorides and bromides with the bifunctional C(sp(3))-(trimethylsilyl)methyllithium reagent is reported. The use of Pd-PEPPSI-IPent as the catalyst allows for the preparation of structurally diverse and synthetically versatile benzyl- and allylsilanes in high yields under mild conditions (room temperature) with short reaction times.
摘要
报道了钯催化的一系列有机氯化物和溴化物与双功能 C(sp(3))-(三甲基甲硅烷基)甲基锂试剂的直接交叉偶联。使用 Pd-PEPPSI-IPent 作为催化剂，可以在温和条件（室温）下以较短的反应时间高产率制备结构多样且合成用途广泛的苄基和烯丙基硅烷。
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