School of Chemistry, Sambalpur University, Jyoti Vihar, Burla, Odisha, 768 019, India.
School of Chemistry, Sambalpur University, Jyoti Vihar, Burla, Odisha, 768 019, India; Centre of Excellence in Natural Products and Therapeutics, Sambalpur University, Jyoti Vihar, Burla, Odisha, 768 019, India.
Chem Phys Lipids. 2021 Jan;234:105025. doi: 10.1016/j.chemphyslip.2020.105025. Epub 2020 Dec 7.
Membrane fusion is an important event in the life of eukaryotes; occurs in several processes such as endocytosis, exocytosis, cellular trafficking, compartmentalization, import of nutrients and export of waste, vesiculation, inter cellular communication, and fertilization. The enveloped viruses as well utilize fusion between the viral envelope and host cell membrane for infection. The stretch of 20-25 amino acids located at the N-terminus of the fusion protein, known as fusion peptide, plays a decisive role in the fusion process. The stalk model of membrane fusion postulated a common route of bilayer transformation for stalk, transmembrane contact, and pore formation; and fusion peptide is believed to facilitate bilayer transformation to promote membrane fusion. The peptide-induced change in depth-dependent organization and dynamics could provide important information in understanding the role of fusion peptide in membrane fusion. In this review, we have discussed about three depth-dependent properties of the membrane such as rigidity, polarity and heterogeneity, and the impact of fusion peptide on these three membrane properties.
膜融合是真核生物生命中的一个重要事件；发生在几个过程中，如内吞作用、外排作用、细胞运输、区室化、营养物质的输入和废物的输出、囊泡形成、细胞间通讯和受精。包膜病毒也利用病毒包膜和宿主细胞膜之间的融合来感染。位于融合蛋白 N 端的 20-25 个氨基酸的伸展，称为融合肽，在融合过程中起着决定性的作用。膜融合的柄模型假定了柄、跨膜接触和孔形成的双层转化的共同途径；融合肽被认为有助于双层转化以促进膜融合。肽诱导的深度相关组织和动力学变化可以为理解融合肽在膜融合中的作用提供重要信息。在这篇综述中，我们讨论了膜的三个深度相关特性，即刚性、极性和异质性，以及融合肽对这三个膜特性的影响。
