Falanga Annarita, Cantisani Marco, Pedone Carlo, Galdiero Stefania
Department of Biological Sciences, Division of Biostructures and Centro Interuniversitario di Ricerca sui Peptidi Bioattivi - University of Naples Federico II, and Istituto di Biostrutture e Bioimmagini - CNR, Via Mezzocannone 16, Napoli 80134, Italy.
Protein Pept Lett. 2009;16(7):751-9. doi: 10.2174/092986609788681760.
Membrane fusion and fission are two key processes that occur during the replication of enveloped viruses, namely access to the interior of the host-cell (entry, which requires fusion of the viral envelope with the target cell envelope) and dissemination of viral progeny after replication (egress, which involves budding and fission). These dynamic processes are mediated by specialized proteins that modify and bend the lipid bilayer transiently and locally. This review focuses on fusion and fission reactions and on the hypothetical shared mechanism that generates their driving force.
膜融合和裂变是包膜病毒复制过程中发生的两个关键过程，即进入宿主细胞内部（进入，这需要病毒包膜与靶细胞膜融合）以及复制后病毒后代的传播（出芽，这涉及出芽和裂变）。这些动态过程由专门的蛋白质介导，这些蛋白质会瞬时和局部地修饰和弯曲脂质双层。本文综述聚焦于融合和裂变反应以及产生其驱动力的假设性共同机制。
