COVID-19 患者肝素治疗中活化部分凝血活酶时间和抗因子 Xa 水平的不相符。
Discordance in activated partial thromboplastin time and anti-factor Xa levels in COVID-19 patients on heparin therapy.
机构信息
Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, 630 W 168th St, New York, NY 10032, United States oF America.
Division of Hematology/Oncology, Department of Medicine, Columbia University Irving Medical Center, 630 W 168th St, New York, NY 10032, United States of America.
出版信息
Thromb Res. 2021 Feb;198:79-82. doi: 10.1016/j.thromres.2020.11.030. Epub 2020 Nov 28.
• aPTT correlates poorly with anti-Xa in COVID-19 patients receiving unfractionated heparin. • aPTT potentially underestimates heparin activity compared with anti-Xa in COVID-19 patients receiving unfractionated heparin. • Elevated fibrinogen levels did not correlate with refractory aPTT in COVID-19 patients.
• COVID-19 患者使用未分级肝素时，APTT 与抗 Xa 相关性差。
• COVID-19 患者使用未分级肝素时，与抗 Xa 相比，APTT 可能低估肝素活性。
• 纤维蛋白原水平升高与 COVID-19 患者难治性 APTT 不相关。
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