Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-Evaluation of Post-Marketed TCM, State Key Laboratory of Biocontrol and Guangdong Provincial Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Biomolecules. 2020 Dec 8;10(12):1644. doi: 10.3390/biom10121644.
Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by incompletely reversible airflow limitation and seriously threatens the health of humans due to its high morbidity and mortality. Naringenin, as a natural flavanone, has shown various potential pharmacological activities against multiple pathological stages of COPD, but available studies are scattered and unsystematic. Thus, we combined literature review with network pharmacology analysis to evaluate the potential therapeutic effects of naringenin on COPD and predict its underlying mechanisms, expecting to provide a promising tactic for clinical treatment of COPD.
慢性阻塞性肺疾病（COPD）是一种慢性呼吸系统疾病，其特征是气流受限不完全可逆，由于其高发病率和死亡率，严重威胁着人类的健康。柚皮素作为一种天然的类黄酮，已经显示出对 COPD 的多个病理阶段具有多种潜在的药理活性，但现有研究较为分散且不系统。因此，我们将文献综述与网络药理学分析相结合，评估柚皮素对 COPD 的潜在治疗作用，并预测其潜在机制，期望为 COPD 的临床治疗提供一个有前景的策略。
