State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Department of Gynecologic Oncology, Hunan Cancer Hospital, the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan Province, China.
Cell Signal. 2020 May;69:109433. doi: 10.1016/j.cellsig.2019.109433. Epub 2020 Jan 23.
In mammals, 24-h rhythms of behaviour and physiology are regulated by the circadian clock. The circadian clock is controlled by a central clock in the brain's suprachiasmatic nucleus (SCN) that synchronizes peripheral clocks in peripheral tissues. Clock genes in the SCN are primarily entrained by light. Increasing evidence has shown that peripheral clocks are also regulated by light and hormones independent of the SCN. How the peripheral clocks deal with internal signals is dependent on the relevance of a specific cue to a specific tissue. In different tissues, most genes that are under circadian control are not overlapping, revealing the tissue-specific control of peripheral clocks. We will discuss how different signals control the peripheral clocks in different peripheral tissues, such as the liver, gastrointestinal tract, and pancreas, and discuss the organ-to-organ communication between the peripheral clocks at the molecular level.
在哺乳动物中，行为和生理学的 24 小时节律由生物钟调节。生物钟受大脑视交叉上核（SCN）中的中央时钟控制，该时钟使外周组织中的外周时钟同步。SCN 中的时钟基因主要通过光进行同步。越来越多的证据表明，外周时钟也受光和激素的调节，而不受 SCN 的影响。外周时钟如何处理内部信号取决于特定线索与特定组织的相关性。在不同的组织中，受昼夜节律控制的大多数基因并不重叠，这揭示了外周时钟的组织特异性控制。我们将讨论不同信号如何控制不同外周组织中的外周时钟，如肝脏、胃肠道和胰腺，并讨论分子水平上外周时钟之间的器官间通讯。
