葡萄球菌皮肤和软组织感染。

Staphylococcal Skin and Soft Tissue Infections.

机构信息

Division of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA, USA; Division of HIV, Harbor-UCLA Medical Center, Torrance, CA, USA; Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA; David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Division of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA, USA; Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA; David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Harbor-UCLA Medical Center, 1000 West Carson Street, Box 466, Torrance, CA 90509, USA.

出版信息

Infect Dis Clin North Am. 2021 Mar;35(1):81-105. doi: 10.1016/j.idc.2020.10.003. Epub 2020 Dec 7.

DOI:10.1016/j.idc.2020.10.003

PMID:33303329

Abstract

Staphylococcus aureus is the most common bacteria causing purulent skin and soft tissue infections. Many disease-causing S aureus strains are methicillin resistant; thus, empiric therapy should be given to cover methicillin-resistant S aureus. Bacterial wound cultures are important for characterizing local susceptibility patterns. Definitive antibiotic therapy is warranted, although there are no compelling data demonstrating superiority of any one antibiotic over another. Antibiotic choice is predicated by the infection severity, local susceptibility patterns, and drug-related safety, tolerability, and cost. Response to therapy is expected within the first days; 5 to 7 days of therapy is typically adequate to achieve cure.

摘要

金黄色葡萄球菌是引起化脓性皮肤和软组织感染最常见的细菌。许多致病的金黄色葡萄球菌菌株对甲氧西林耐药；因此，经验性治疗应覆盖耐甲氧西林金黄色葡萄球菌。细菌伤口培养对于描述局部药敏模式非常重要。虽然没有确凿的数据表明任何一种抗生素优于另一种抗生素，但需要进行明确的抗生素治疗。抗生素的选择取决于感染的严重程度、局部药敏模式以及药物的安全性、耐受性和成本。预计在最初几天内会有治疗反应；通常需要 5 到 7 天的治疗才能达到治愈。