Corrêa Diogo G, van Duinkerken Eelco, Zimmermann Nicolle, Fonseca Rochele P, Gasparetto Emerson L
Department of Radiology, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
Clínica de Diagnóstico por Imagem (CDPI)/DASA, Rio de Janeiro, RJ, Brazil.
Radiol Bras. 2020 Nov-Dec;53(6):359-365. doi: 10.1590/0100-3984.2019.0093.
We aimed to evaluate whether human immunodeficiency virus (HIV)-positive patients with and without clinically significant memory deficits and healthy control participants differ on in vivo hydrogen-1 magnetic resonance spectroscopy (H-MRS) in the posterior cingulate gyri.
In total, 21 HIV-positive patients with memory deficit (HIV+wMD) were compared with 15 HIV-positive patients without memory deficit (HIV+wOMD) and 22 sex-, age-, and education-matched control participants. Memory impairments were classified based on the participants' performance on the Rey Auditory Verbal Learning Test. Short echo time (30 ms), single-voxel H-MRS was performed using a 1.5-T magnetic resonance scanner.
The HIV+wMD and HIV+wOMD groups had higher choline/creatine ratio in the posterior cingulate gyri than the control group. There were no significant metabolite ratio differences between the HIV+wMD and HIV+wOMD groups.
HIV-positive patients with and without memory deficits had significantly higher choline/creatine ratios than controls in the posterior cingulate gyri, which may reflect cerebral inflammation, altered cell membrane metabolism, microgliosis, and/or astrocytosis.
我们旨在评估有和没有临床显著记忆缺陷的人类免疫缺陷病毒（HIV）阳性患者以及健康对照参与者在后扣带回的体内氢-1磁共振波谱（H-MRS）是否存在差异。
总共将21名有记忆缺陷的HIV阳性患者（HIV+wMD）与15名无记忆缺陷的HIV阳性患者（HIV+wOMD）以及22名性别、年龄和教育程度匹配的对照参与者进行比较。根据参与者在雷伊听觉词语学习测验中的表现对记忆损害进行分类。使用1.5-T磁共振扫描仪进行短回波时间（30 ms）的单体素H-MRS。
HIV+wMD组和HIV+wOMD组后扣带回中的胆碱/肌酸比值高于对照组。HIV+wMD组和HIV+wOMD组之间的代谢物比值无显著差异。
有和没有记忆缺陷的HIV阳性患者后扣带回中的胆碱/肌酸比值均显著高于对照组，这可能反映了脑部炎症、细胞膜代谢改变、小胶质细胞增生和/或星形细胞增生。
