Qian Shaowen, Zhang Jing, Yan Sumei, Shi Zhiyue, Wang Zhaoqun, Zhou Yi
Department of Neurobiology, Chongqing Key Laboratory of Neurobiology, Army Medical University, Chongqing, China.
Department of Medical Imaging, Jinan Military General Hospital, Jinan, China.
Front Hum Neurosci. 2020 Nov 12;14:564272. doi: 10.3389/fnhum.2020.564272. eCollection 2020.
Environmental hyperthermia is a common risk factor for occupational safety in many situations due to decreased vigilance performances. Previously, we have reported that decreased resting-state functional connectivity within the default mode network (DMN) and decreased activations in dorsal attention network (DAN) such as dorsolateral prefrontal cortex (DLPFC) were correlated with selective attention deficits during hyperthermia. However, whether the inherent functionally organized anti-correlation between the DMN and DAN would contribute to the behavioral deficits remains unclear. In this study, we collected the resting-state fMRI data of 25 participants during two simulated thermal conditions: normothermic condition (25°C for 1 h) and hyperthermic condition (50°C for 1 h). Using group independent component analysis (ICA), we investigated the functional connectivity within the DMN and DAN, as well as the anti-correlations between both networks. Paired comparisons revealed that decreased intranetwork functional connectivity in the medial prefrontal cortex (mPFC)/anterior cingulate cortex (ACC) in the DMN contributed to executive control performance during hyperthermia using multivariate linear regression analysis. Paired comparison on the DAN showed that increased one in the posterior part of the middle and inferior temporal gyrus nearby the temporal-parietal junction area contributed to preserved alerting performance. Lastly but most importantly, we found that decreased correlation between mPFC in the DMN and intraparietal sulcus (IPS) area in the DAN contributed to the executive control deficit, suggesting a weaker intrinsic anti-correlation between DMN and DAN during hyperthermia. These findings indicated that a functional reorganized architecture of DMN and DAN might provide a potential neural basis of the selective deficits for different cognitive-demand attention tasks in high-temperature environments.
由于警觉性表现下降，环境高温在许多情况下是职业安全的常见风险因素。此前，我们曾报道，默认模式网络（DMN）内静息态功能连接性降低以及背侧注意网络（DAN）如背外侧前额叶皮层（DLPFC）的激活减少与高温期间的选择性注意缺陷相关。然而，DMN和DAN之间固有的功能组织反相关性是否会导致行为缺陷仍不清楚。在本研究中，我们收集了25名参与者在两种模拟热条件下的静息态功能磁共振成像数据：常温条件（25°C，持续1小时）和高温条件（50°C，持续1小时）。使用组独立成分分析（ICA），我们研究了DMN和DAN内的功能连接性以及两个网络之间的反相关性。配对比较显示，使用多元线性回归分析，DMN中内侧前额叶皮层（mPFC）/前扣带回皮层（ACC）内网络内功能连接性降低导致了高温期间的执行控制表现。对DAN的配对比较表明，颞顶交界区附近颞中回和颞下回后部的一个增加有助于保持警觉表现。最后但最重要的是，我们发现DMN中的mPFC与DAN中的顶内沟（IPS）区域之间的相关性降低导致了执行控制缺陷，这表明高温期间DMN和DAN之间的内在反相关性较弱。这些发现表明，DMN和DAN的功能重组结构可能为高温环境中不同认知需求注意任务的选择性缺陷提供潜在的神经基础。
