Zhang Wei, Wang Fei, Hu Chuan, Zhou Yang, Gao Huile, Hu Jiang
Department of Orthopedics, Sichuan Provincial People's Hospital & Sichuan Academy of Medical Sciences & Affiliated Hospital of University of Electronic Science and Technology, Chengdu 610072, China.
Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy Sichuan University, Chengdu 610041, China.
Acta Pharm Sin B. 2020 Nov;10(11):2037-2053. doi: 10.1016/j.apsb.2020.07.013. Epub 2020 Jul 26.
As one of the most serious threats to human being, cancer is hard to be treated when metastasis happens. What's worse, there are few identified targets of metastasis for drug development. Therefore, it is important to develop strategies to prevent metastasis or treat existed metastasis. This review focuses on the procedure of metastasis, and first summarizes the targeting delivery strategies, including primary tumor targeting drug delivery, tumor metastasis targeting drug delivery and hijacking circulation cells. Then, as a promising treatment, the application of immunotherapy in tumor metastasis treatment is introduced, and strategies that stimulating immune response are reviewed, including chemotherapy, photothermal therapy, photodynamic therapy, ferroptosis, sonodynamic therapy, and nanovaccines. Finally, the challenges and perspective about nanoparticle-enabled tumor metastasis treatment are discussed.
作为对人类最严重的威胁之一，癌症在发生转移时很难治疗。更糟糕的是，用于药物开发的已确定转移靶点很少。因此，制定预防转移或治疗已发生转移的策略很重要。本综述聚焦于转移过程，首先总结了靶向递送策略，包括原发性肿瘤靶向药物递送、肿瘤转移靶向药物递送和劫持循环细胞。然后，作为一种有前景的治疗方法，介绍了免疫疗法在肿瘤转移治疗中的应用，并综述了刺激免疫反应的策略，包括化疗、光热疗法、光动力疗法、铁死亡、声动力疗法和纳米疫苗。最后，讨论了纳米颗粒介导的肿瘤转移治疗面临的挑战和前景。
