载药树枝状高分子纳米粒治疗肺癌骨转移
Bone-targeted PAMAM nanoparticle to treat bone metastases of lung cancer.
机构信息
Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an, 710032, PR China.
Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of The State Administration of Traditional Chinese Medicine, Fourth Military Medical University, Xi'an, 710032, PR China.
出版信息
Nanomedicine (Lond). 2020 Apr;15(9):833-849. doi: 10.2217/nnm-2020-0024. Epub 2020 Mar 12.
To prepare pH-sensitive nanoparticle composed of alendronate (ALN) and poly(amidoamine) (PAMAM) to treat bone metastases of lung cancer. The solvent evaporation method was used to prepare docetaxel (DTX)-loaded ALN-PAMAM nanoparticles (DTX@ALN-PAMAM). The results showed DTX@ALN-PAMAM significantly enhanced the anticancer activity of DTX and inhibited the formation of osteoclasts. DTX@ALN-PAMAM concentrated at bone metastasis site in mice, which resulted in the suppression of bone resorption, pain response and growth of bone metastases. Eventually, the therapeutic effect of DTX on bone metastases of lung cancer was obviously improved. ALN modified PAMAM nanoparticle could be an effective platform for the treatment of bone metastases of lung cancer.
制备阿仑膦酸钠（ALN）和聚酰胺-胺（PAMAM）组成的 pH 敏感纳米粒子，用于治疗肺癌骨转移。采用溶剂蒸发法制备多西紫杉醇（DTX）负载的 ALN-PAMAM 纳米粒子（DTX@ALN-PAMAM）。结果表明，DTX@ALN-PAMAM 显著增强了 DTX 的抗癌活性，并抑制破骨细胞的形成。DTX@ALN-PAMAM 在小鼠的骨转移部位聚集，从而抑制了骨吸收、疼痛反应和骨转移的生长。最终，明显改善了 DTX 对肺癌骨转移的治疗效果。ALN 修饰的 PAMAM 纳米粒子可能成为治疗肺癌骨转移的有效平台。
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