Chen Rujing, Huang Leaf, Hu Kaili
Murad Research Center for Modernized Chinese Medicine, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Division of Pharmacoengineering and Molecular Pharmaceutics, Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Acta Pharm Sin B. 2020 Nov;10(11):2140-2155. doi: 10.1016/j.apsb.2020.04.005. Epub 2020 Apr 19.
Desmoplastic tumors have an abundance of stromal cells and the extracellular matrix which usually result in therapeutic resistance. Current treatment prescriptions for desmoplastic tumors are usually not sufficient to eliminate the malignancy. Recently, through modulating cancer-associated fibroblasts (CAFs) which are the most abundant cell type among all stromal cells, natural products have improved chemotherapies and the delivery of nanomedicines to the tumor cells, showing promising ability to improve treatment effects on desmoplastic tumors. In this review, we discussed the latest advances in inhibiting desmoplastic tumors by modeling CAFs using natural products, highlighting the potential therapeutic abilities of natural products in targeting CAFs for cancer treatment.
促结缔组织增生性肿瘤含有大量基质细胞和细胞外基质，这通常会导致治疗耐药性。目前针对促结缔组织增生性肿瘤的治疗方案通常不足以消除恶性肿瘤。最近，天然产物通过调节癌症相关成纤维细胞（CAFs）（所有基质细胞中最丰富的细胞类型），改善了化疗效果以及纳米药物向肿瘤细胞的递送，显示出有望提高对促结缔组织增生性肿瘤的治疗效果。在这篇综述中，我们讨论了利用天然产物对CAFs进行建模来抑制促结缔组织增生性肿瘤的最新进展，强调了天然产物在靶向CAFs进行癌症治疗方面的潜在治疗能力。
