Luo Lifeng, Zhou Jieru, Liu Xiaonan, Chen Yanyu, Du Xiao, Gao Lili, Sun Yunting, Wang Shuling
School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.
School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China; Department of Neurology, The Second Affiliated Hospital of Fujian Traditional Chinese Medical University, Fuzhou, Fujian 350003, China.
J Adv Res. 2024 Aug 5. doi: 10.1016/j.jare.2024.08.005.
Traditional Chinese Medicine (TCM) has gained global attention, particularly after Professor Youyou Tu was awarded the Nobel Prize for her discovery of artemisinin as a treatment for malaria. However, the theory behind TCM is often perceived as a "black-box" with complex components and an unclear structure and mechanism of action. This had hindered the development of TCM within the framework of modern medicine.
The molecular compatibility theory proposed by Professor Tian Xie's team integrates TCM with Western medicine in clinical practice, and provide a feasible direction for TCM modernization. It is necessary to summarize and popularize this theory. This review aims to systematically introduce this theory to provide some new insight for development of TCM.
According to the molecular compatibility theory, the desired effects can be achieved by organically combining multiple active molecules from TCM. These TCM molecular compounds have specific ingredients, precise mechanisms, and controllable quality that meet the standards of modern medicine. The molecular compatibility theory has guided the development of antitumor new drug elemene emulsions, and has also revealed extensive compatibility between TCM-derived active molecules and other TCM, Western medicine, or biomaterials. This discovery opens up potential TCM-based treatment options. In conclusion, the molecular compatibility theory holds promise as a strategy for modernizing TCM.
中医药已获得全球关注，尤其是在屠呦呦教授因发现青蒿素治疗疟疾而获得诺贝尔奖之后。然而，中医药背后的理论通常被视为一个“黑匣子”，其组成部分复杂，结构和作用机制不明。这阻碍了中医药在现代医学框架内的发展。
田捷教授团队提出的分子配伍理论将中医药与西医在临床实践中相结合，为中医药现代化提供了可行的方向。有必要对这一理论进行总结和推广。本综述旨在系统介绍这一理论，为中医药的发展提供一些新的见解。
根据分子配伍理论，通过有机结合多种中药活性分子可达到预期效果。这些中药分子化合物具有特定成分、精确机制和可控质量，符合现代医学标准。分子配伍理论指导了抗肿瘤新药榄香烯乳剂的研发，还揭示了中药来源的活性分子与其他中药、西药或生物材料之间广泛的配伍性。这一发现开辟了基于中医药的潜在治疗选择。总之，分子配伍理论有望成为中医药现代化的一种策略。
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