Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Chemical Biology Key Laboratory of Hebei Province, College of Chemistry & Environmental Science, Institute of Life Science and Green development, Hebei University, Baoding 071002, P. R. China.
Department of Radiology, Tianjin First Central Hospital, First Central Clinical College of Tianjin Medical University, Tianjin, 300192, P. R. China.
J Mater Chem B. 2021 Jan 14;9(2):314-321. doi: 10.1039/d0tb02514c. Epub 2020 Dec 11.
Multifunctional nanoprobes with tumor microenvironment response are playing important roles in highly efficient theranostics of cancers. Herein, a kind of theranostic nanoprobe was synthesized by coating manganese dioxide (MnO) on the surface of black commercial P25 titanium dioxide (b-P25). The resultant nanoprobe (b-P25@MnO) possessed glutathione (GSH)-responsive magnetic resonance (MR) imaging and enhanced photothermal therapy (PTT). In tumor microenvironments, the excessive GSH was consumed by reacting with MnO to generate Mn for GSH-responsive MR imaging, in which the longitudinal relaxation rate of b-P25@MnO was up to 30.44 mM s, showing excellent cellular and intratumoral MR imaging. Moreover, the prepared b-P25@MnO exhibited stable and strong photothermal conversion capability with a high photothermal conversion efficiency of 30.67%, by which the 4T1 tumors disappeared completely, indicating safe and highly efficient PTT performance. The current work developed GSH-responsive b-P25@MnO nanoprobes, demonstrated for MR imaging and enhanced PTT in cancers.
具有肿瘤微环境响应的多功能纳米探针在癌症的高效治疗中发挥着重要作用。在此，通过在商用黑钛白粉（b-P25）表面包覆二氧化锰（MnO）合成了一种诊疗纳米探针。所得的纳米探针（b-P25@MnO）具有谷胱甘肽（GSH）响应磁共振（MR）成像和增强光热治疗（PTT）的功能。在肿瘤微环境中，过量的 GSH 与 MnO 反应消耗以产生 Mn 用于 GSH 响应的 MR 成像，其中 b-P25@MnO 的纵向弛豫率高达 30.44mM s，表现出优异的细胞内和肿瘤内的 MR 成像效果。此外，所制备的 b-P25@MnO 表现出稳定且强的光热转换能力，具有 30.67%的高光热转换效率，可使 4T1 肿瘤完全消失，表明其具有安全高效的 PTT 性能。本工作开发了 GSH 响应性 b-P25@MnO 纳米探针，用于癌症的 MR 成像和增强 PTT。
