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用于基于磁共振成像的多模态成像与诊疗的氧化锰纳米颗粒

Manganese Oxide Nanoparticles for MRI-Based Multimodal Imaging and Theranostics.

作者信息

Geraldes Carlos F G C

机构信息

Department of Life Sciences and Coimbra Chemistry Center-Institute of Molecular Sciences (CQC-IMS), Faculty of Science and Technology, University of Coimbra, 3004-531 Coimbra, Portugal.

CIBIT-Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, 3004-531 Coimbra, Portugal.

出版信息

Molecules. 2024 Nov 26;29(23):5591. doi: 10.3390/molecules29235591.

DOI:10.3390/molecules29235591
PMID:39683750
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11643175/
Abstract

Manganese-based MRI contrast agents have recently attracted much attention as an alternative to Gd-based compounds. Various nanostructures have been proposed for potential applications in in vivo diagnostics and theranostics. This review is focused on the discussion of different types of Mn oxide-based nanoparticles (MnO NPs) obtained at the +2, +3 and +4 oxidation states for MRI, multimodal imaging or theranostic applications. These NPs show favorable magnetic properties, good biocompatibility, and an improved toxicity profile relative to Gd(III)-based nanosystems, showing that the Mn paramagnetic ions offer advantages for the next generation of nanoscale MRI and theranostic contrast agents. Their potential for enhancing relaxivity and MRI contrast effects is illustrated through discussion of selected examples published in the past decade.

摘要

作为基于钆的化合物的替代品，锰基磁共振成像（MRI）造影剂最近备受关注。人们提出了各种纳米结构用于体内诊断和治疗诊断学的潜在应用。本综述着重讨论了在+2、+3和+4氧化态下获得的不同类型的基于氧化锰的纳米颗粒（MnO NPs），用于MRI、多模态成像或治疗诊断学应用。相对于基于Gd(III)的纳米系统，这些纳米颗粒表现出良好的磁性能、生物相容性和改善的毒性特征，表明锰顺磁性离子为下一代纳米级MRI和治疗诊断造影剂提供了优势。通过讨论过去十年发表的选定实例，阐述了它们增强弛豫率和MRI造影效果的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/693c/11643175/bb4c6eb3e318/molecules-29-05591-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/693c/11643175/133a36854f84/molecules-29-05591-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/693c/11643175/87f9a0b5d7b2/molecules-29-05591-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/693c/11643175/ad98ddd53b2a/molecules-29-05591-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/693c/11643175/173dcff8bb47/molecules-29-05591-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/693c/11643175/3f90f90bda53/molecules-29-05591-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/693c/11643175/bb4c6eb3e318/molecules-29-05591-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/693c/11643175/133a36854f84/molecules-29-05591-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/693c/11643175/87f9a0b5d7b2/molecules-29-05591-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/693c/11643175/ad98ddd53b2a/molecules-29-05591-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/693c/11643175/173dcff8bb47/molecules-29-05591-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/693c/11643175/3f90f90bda53/molecules-29-05591-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/693c/11643175/bb4c6eb3e318/molecules-29-05591-g006.jpg

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Manganese Oxide Nanoparticles for MRI-Based Multimodal Imaging and Theranostics.

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引用本文的文献

[1]
Mn-Doped Carbon Dots as Contrast Agents for Magnetic Resonance and Fluorescence Imaging.

Int J Mol Sci. 2025-6-29

[2]
Visual analysis of emerging topics and trends in contrast agent extravasation research in medical imaging: a bibliometric study using CiteSpace and VOSviewer.

Front Med (Lausanne). 2025-2-19

本文引用的文献

[1]
Rutin-coated ultrasmall manganese oxide nanoparticles for targeted magnetic resonance imaging and photothermal therapy of malignant tumors.

J Colloid Interface Sci. 2024-9-15

[2]
Rational Design of Magnetic Nanoparticles as T-T Dual-Mode MRI Contrast Agents.

Molecules. 2024-3-18

[3]
Hybrids of manganese oxide and lipid liquid crystalline nanoparticles (LLCNPs@MnO) as potential magnetic resonance imaging (MRI) contrast agents.

J Mater Chem B. 2023-9-20

[4]
Caveat Emptor: Commercialized Manganese Oxide Nanoparticles Exhibit Unintended Properties.

ACS Omega. 2023-5-18

[5]
Ultra-small manganese dioxide nanoparticles with high relaxivity for magnetic resonance angiography.

Biomater Sci. 2023-6-13

[6]
Multifunctional tunable ZnFeO@MnFeO nanoparticles for dual-mode MRI and combined magnetic hyperthermia with radiotherapy treatment.

J Mater Chem B. 2023-2-1

[7]
Novel manganese and polyester dendrimer-based theranostic nanoparticles for MRI and breast cancer therapy.

J Mater Chem B. 2023-1-18

[8]
Holographically Activatable Nanoprobe via Glutathione/Albumin-Mediated Exponential Signal Amplification for High-Contrast Tumor Imaging.

Adv Mater. 2023-3

[9]
Mn Bispidine Complex Combining Exceptional Stability, Inertness, and MRI Efficiency.

J Am Chem Soc. 2022-12-7

[10]
High spin Fe(III)-doped nanostructures as T MR imaging probes.

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2023-3

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