Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi, China.
Crit Rev Food Sci Nutr. 2022;62(9):2508-2525. doi: 10.1080/10408398.2020.1854673. Epub 2020 Dec 11.
The aim of this systematic review and meta-analysis was to analyze data from randomized controlled trials (RCTs) assessing the effects of oleic acid (OA) supplementation on blood inflammatory markers in adults. PubMed, EMBASE and Cochrane Library databases were systematically searched from 1950 to 2019, with adults and a minimum intervention duration of 4 weeks. The effect size was estimated, adopting standardized mean difference (SMD) and 95% confidence interval (CI). Of the 719 identified studies, thirty-one RCTs involving 1634 subjects were eligible. The results of this study revealed that increasing OA supplementation significantly reduced C-reactive protein (CRP) (SMD: -0.11, 95% CI: -0.21, -0.01, P = 0.038). However, dietary OA consumption did not significantly affect tumor necrosis factor (TNF) (SMD: -0.05, 95% CI: -0.19, 0.10, P = 0.534), interleukin 6 (IL-6) (SMD: 0.01, 95% CI: -0.10, 0.13, P = 0.849), fibrinogen (SMD: 0.08, 95% CI: -0.16, 0.31, P = 0.520), plasminogen activator inhibitor type 1 (PAI-1) activity (SMD: -0.11, 95% CI: -0.34, 0.12, P = 0.355), soluble intercellular adhesion molecule-1 (sICAM-1) (SMD: -0.06, 95% CI: -0.26, 0.13, P = 0.595) or soluble vascular cell adhesion molecule-1 (sVCAM-1) (SMD: -0.04, 95% CI: -0.27, 0.18, P = 0.701). Overall, the meta-analysis demonstrated that dietary OA supplementation significantly reduced CRP, yet did not affect other inflammatory markers including TNF, IL-6, fibrinogen, PAI-1 activity, sICAM-1or sVCAM-1.
本系统评价和荟萃分析的目的是分析评估油酸（OA）补充对成年人血液炎症标志物影响的随机对照试验（RCT）的数据。从 1950 年到 2019 年，我们系统地检索了 PubMed、EMBASE 和 Cochrane 图书馆数据库，纳入的研究对象为成年人，且干预时间至少为 4 周。采用标准化均数差（SMD）和 95%置信区间（CI）来估计效应量。在确定的 719 项研究中，有 31 项 RCT 符合条件，涉及 1634 名受试者。研究结果表明，增加 OA 补充可显著降低 C 反应蛋白（CRP）（SMD：-0.11，95%CI：-0.21，-0.01，P=0.038）。然而，膳食 OA 消耗对肿瘤坏死因子（TNF）（SMD：-0.05，95%CI：-0.19，0.10，P=0.534）、白细胞介素 6（IL-6）（SMD：0.01，95%CI：-0.10，0.13，P=0.849）、纤维蛋白原（SMD：0.08，95%CI：-0.16，0.31，P=0.520）、纤溶酶原激活物抑制剂 1 活性（SMD：-0.11，95%CI：-0.34，0.12，P=0.355）、可溶性细胞间黏附分子 1（sICAM-1）（SMD：-0.06，95%CI：-0.26，0.13，P=0.595）或可溶性血管细胞黏附分子 1（sVCAM-1）（SMD：-0.04，95%CI：-0.27，0.18，P=0.701）没有影响。总的来说，荟萃分析表明，膳食 OA 补充可显著降低 CRP，但对 TNF、IL-6、纤维蛋白原、PAI-1 活性、sICAM-1 或 sVCAM-1 等其他炎症标志物没有影响。
