Federal State Budgetary Scientific Institution "Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott", Saint Petersburg, Russia.
Gynecol Endocrinol. 2020;36(sup1):1-6. doi: 10.1080/09513590.2020.1816715.
The present study was to estimate the role of cytokines for trophoblast death in NK cells presence.
This study involves assessment of NK-92 line NK cell cytotoxic activity against JEG-3 line cells, in presence of cytokines. We also assessed the effect of secretory placenta products on NK cell cytotoxic activity toward JEG-3 line cells.
Uteroplacental contact zone cytokines are able to enhance trophoblast mortality both by themselves in case of IL-1β, IL-6, IFNγ, IL-4, TGFβ, bFGF, and also through increasing the cytotoxic potential of NK cells in case of IL-1β, IFNγ, IL-8, TGFβ, and GM-CSF. PLGF decreases NK cell cytotoxicity for trophoblasts. Secretory products of first trimester placenta enhance NK cell cytotoxic potential for trophoblasts.
Cytokines of the uteroplacental contact zone can appear a mechanism ensuring trophoblast mortality dynamics throughout pregnancy.
本研究旨在评估细胞因子在 NK 细胞存在下对滋养层细胞死亡的作用。
本研究评估了 NK-92 细胞系 NK 细胞在细胞因子存在的情况下对 JEG-3 细胞系的细胞毒性作用，还评估了胎盘分泌产物对 NK 细胞对 JEG-3 细胞系细胞毒性作用的影响。
滋养层接触区细胞因子本身（如 IL-1β、IL-6、IFNγ、IL-4、TGFβ、bFGF）就能够增强滋养层的死亡率，并且还能通过增加 NK 细胞的细胞毒性作用（如 IL-1β、IFNγ、IL-8、TGFβ 和 GM-CSF）来增强滋养层的死亡率。PLGF 降低了 NK 细胞对滋养层的细胞毒性。胎盘的第一孕期分泌产物增强了 NK 细胞对滋养层的细胞毒性作用。
滋养层接触区的细胞因子可能是确保整个孕期滋养层细胞死亡动力学的一种机制。
