Department of Histology and Embryology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
Anat Histol Embryol. 2021 Mar;50(2):396-403. doi: 10.1111/ahe.12644. Epub 2020 Dec 11.
Hofbauer cells are macrophages residing in the stroma of placental villi and play a number of roles during normal pregnancy, as well as pathological conditions. A morphometric analysis of Hofbauer cells, in particular to investigate the number of cells, their size and shape in samples of normal human placenta from 1st trimester, term and with chorioamnionitis was performed. Tissue samples were immunostained for CD206 antigen and evaluated using ImageJ software. We detected significant changes in number and morphology of HBCs between normal placenta and placenta with chorioamnionitis samples. In chorioamnionitis, the cells were unevenly distributed within the villi, generally present in higher numbers, larger and more elongated than those in normal 1st trimester and term placenta.
Hofbauer 细胞是驻留在胎盘绒毛间质中的巨噬细胞，在正常妊娠和病理情况下发挥多种作用。我们对 Hofbauer 细胞进行了形态计量学分析，特别是研究了 1 期、足月和绒毛膜羊膜炎正常人类胎盘样本中细胞数量、大小和形状。组织样本用 CD206 抗原进行免疫染色，并使用 ImageJ 软件进行评估。我们在正常胎盘和绒毛膜羊膜炎样本之间检测到 Hofbauer 细胞数量和形态的显著变化。在绒毛膜羊膜炎中，细胞在绒毛内不均匀分布，通常数量较多，比正常 1 期和足月胎盘的细胞更大、更长。
