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载多巴胺纳米粒子作为纳米酶用于增强光动力和光热治疗。

Pt@polydopamine nanoparticles as nanozymes for enhanced photodynamic and photothermal therapy.

机构信息

School of Public Health, Shandong University, Jinan, Shandong Province, China.

出版信息

Chem Commun (Camb). 2021 Jan 7;57(2):255-258. doi: 10.1039/d0cc07355e. Epub 2020 Dec 11.

DOI:10.1039/d0cc07355e
PMID:33306071
Abstract

Polydopamine nanoparticles were used to stabilize a nano-Pt catalyst to relieve tumour hypoxia in photodynamic therapy (PDT). Polydopamine not only provides a platform for carrying nano-Pt and photosensitizers but is also used as a photothermal reagent for photothermal therapy (PTT). The system presented an enhanced anti-tumor therapy effect through a combined PDT and PTT mechanism.

摘要

聚多巴胺纳米粒子被用于稳定纳米 Pt 催化剂以缓解光动力疗法（PDT）中的肿瘤缺氧。聚多巴胺不仅为携带纳米 Pt 和光敏剂提供了一个平台，而且还被用作光热疗法（PTT）的光热试剂。该系统通过联合 PDT 和 PTT 机制呈现出增强的抗肿瘤治疗效果。

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