金丝桃素和单种金丝桃中的黄酮类化合物。
Chromanopyrones and a flavone from Hypericum monogynum.
机构信息
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, People's Republic of China; School of Pharmacuetical Sciences, Guizhou Medical University, Guiyang 550025, People's Republic of China; Key Laboratory of Chemistry for Natural Products of Guizhou Province, Chinese Academy of Sciences, Guiyang 550014, People's Republic of China.
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, People's Republic of China; Key Laboratory of Chemistry for Natural Products of Guizhou Province, Chinese Academy of Sciences, Guiyang 550014, People's Republic of China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
出版信息
Fitoterapia. 2018 Mar;125:59-64. doi: 10.1016/j.fitote.2017.12.013. Epub 2017 Dec 18.
Six new compounds, including three pyrone derivatives (2-4), one new flavone (5), and two new naturally-occurring compounds (1 and 6), together with 16 known compounds were isolated from the leaves and twigs of Hypericum monogynum. In addition, compounds 2-4 are racemates. Their structures and absolute configurations were determined on the basis of extensive analysis of spectroscopic data and ECD calculation. All compounds were evaluated for the inhibitory effects on α-glucosidase, compounds 1, 5, and 7 showed moderate inhibitory activities with IC values of 161.46, 257.78, and 11.54μg/ml, respectively. Compound 8 exhibited weak anti-oxidant activity with IC value of 12.55μg/ml.
从贯叶金丝桃的叶和嫩枝中分离得到了 6 个新化合物，包括 3 个吡喃酮衍生物（2-4）、1 个新黄酮（5）和 2 个新天然产物（1 和 6），此外，化合物 2-4 是外消旋体。基于光谱数据分析和 ECD 计算的广泛分析，确定了它们的结构和绝对构型。所有化合物均进行了对α-葡萄糖苷酶抑制作用的评价，化合物 1、5 和 7 表现出中等抑制活性，IC 值分别为 161.46、257.78 和 11.54μg/ml。化合物 8 表现出较弱的抗氧化活性，IC 值为 12.55μg/ml。
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