Department of Neurology, Faculty of Medical Sciences, Medical University of Warsaw, Warsaw, Poland, Cegłowska 80, 01-809 Warsaw Warsaw, Poland.
Department of Rehabilitation, Central Clinical Hospital of the Ministry of the Interior and Administration in Warsaw, Poland, Wołoska 137, 02-507 Warsaw, 02-507 Warsaw, Poland.
Neurol Neurochir Pol. 2021;55(1):81-90. doi: 10.5603/PJNNS.a2020.0095. Epub 2020 Dec 11.
This study was aimed at assessing the possible effect of melatonin concentration on migraine. The serum concentration profile of melatonin in patients with diagnosed episodic migraine in the interictal period was compared to the profile in patients without migraine. Then, a correlation between the frequency and duration of migraine attacks, and the possible relationship between these parameters and melatonin levels in individual patients, was established.
Melatonin secretion is related to migraine pathophysiology in many different ways.
The study was conducted in a group of 58 subjects (48 women and 10 men). The study group comprised 29 patients (24 women and five men) diagnosed with migraine according to the International Classification of Headache Disorders (ICHD-3 beta), within the framework of the Outpatient Clinic at Bielanski Hospital in Warsaw and the Clinical Department of Neurology of the 2nd Faculty of Medicine (now known as the Faculty of Medical Sciences) at the Medical University of Warsaw, Poland. The control group consisted of 29 subjects (24 women and five men) with no headache. Blood samples for the determination of melatonin were collected at midnight, 2am, 3am, 4am and 6am. Melatonin level in a frozen serum of venous blood was determined by a radio-immuno-enzymatic method at the Department of Histology and Embryology of the Faculty of Veterinary Medicine at the University of Warmia and Mazury in Olsztyn, Poland.
No statistically significant differences between the levels of melatonin and the averaged advances of melatonin profiles were observed in the examined and the control group. There were demonstrated medium negative correlations between the maximum value of melatonin and the duration of migraine (R = -0.4, p = 0.03). There were also observed statistically significant differences (p = 0.01) between the averaged advances of melatonin profiles, depending on the duration of migraine.
Our study showed no abnormalities of melatonin secretion in patients with migraine during the interictal period. The results of studies available in the literature depend on the nature of the headache (episodic or chronic) and the time of measuring the concentration of melatonin (during a headache attack or in an interictal period).
本研究旨在评估褪黑素浓度对偏头痛可能产生的影响。我们比较了发作间期被诊断为偶发性偏头痛的患者与无偏头痛患者的血清褪黑素浓度曲线。然后，我们建立了偏头痛发作频率和持续时间与患者个体中褪黑素水平之间的相关性。
褪黑素的分泌与偏头痛的病理生理学有多种不同的关联。
本研究在波兰华沙比埃兰斯基医院的门诊和华沙第二医学院（现为华沙医科大学医学科学系）神经病学临床系纳入了 58 名受试者（48 名女性和 10 名男性）。研究组包括 29 名偏头痛患者（24 名女性和 5 名男性），这些患者符合国际头痛疾病分类（ICHD-3β）的诊断标准。对照组由 29 名无头痛的受试者组成（24 名女性和 5 名男性）。我们于午夜、凌晨 2 点、凌晨 3 点、凌晨 4 点和凌晨 6 点采集用于测定褪黑素的静脉血样本。在波兰奥尔什丁瓦尔米亚和马祖里大学兽医学院的组织学和胚胎学系，我们采用放射免疫酶分析法测定了冷冻血清中的褪黑素水平。
在研究组和对照组中，褪黑素水平和褪黑素曲线的平均提前量均无统计学差异。在最大褪黑素值和偏头痛持续时间之间存在中等程度的负相关（R = -0.4，p = 0.03）。此外，褪黑素曲线的平均提前量也存在统计学差异（p = 0.01），取决于偏头痛的持续时间。
我们的研究表明，在发作间期，偏头痛患者的褪黑素分泌无异常。现有文献中的研究结果取决于头痛的性质（偶发性或慢性）和褪黑素浓度的测量时间（头痛发作期间或发作间期）。
