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偏头痛信号通路:调节偏头痛和使偏头痛患者易发生头痛的氨基酸代谢物。

Migraine signaling pathways: amino acid metabolites that regulate migraine and predispose migraineurs to headache.

机构信息

College of Osteopathic Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, FL, 34211, USA.

出版信息

Mol Cell Biochem. 2022 Sep;477(9):2269-2296. doi: 10.1007/s11010-022-04438-9. Epub 2022 Apr 28.

DOI:10.1007/s11010-022-04438-9
PMID:35482233
Abstract

Migraine is a common, debilitating disorder for which attacks typically result in a throbbing, pulsating headache. Although much is known about migraine, its complexity renders understanding the complete etiology currently out of reach. However, two important facts are clear, the brain and the metabolism of the migraineur differ from that of the non-migraineur. This review centers on the altered amino acid metabolism in migraineurs and how it helps define the pathology of migraine.

摘要

偏头痛是一种常见的使人虚弱的疾病,其发作通常会导致搏动性、悸动性头痛。尽管人们对偏头痛有了很多了解,但它的复杂性使得目前还无法完全理解其病因。然而,有两个重要的事实是清楚的,即偏头痛患者的大脑和新陈代谢与非偏头痛患者不同。本综述集中讨论了偏头痛患者氨基酸代谢的改变,以及它如何帮助确定偏头痛的病理。

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Mol Cell Biochem. 2022 Sep;477(9):2269-2296. doi: 10.1007/s11010-022-04438-9. Epub 2022 Apr 28.
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Study of arginine metabolism in medication overuse chronic migraine: possible defect in NO synthesis.药物过度使用性慢性偏头痛患者精氨酸代谢研究:一氧化氮合成可能存在缺陷。
Neurol Sci. 2022 Apr;43(4):2745-2749. doi: 10.1007/s10072-021-05672-7. Epub 2021 Oct 22.
2
Clinical relevance of depressed kynurenine pathway in episodic migraine patients: potential prognostic markers in the peripheral plasma during the interictal period.发作性偏头痛患者抑郁型犬尿氨酸通路的临床相关性:间歇期外周血浆中的潜在预后标志物。
J Headache Pain. 2021 Jun 25;22(1):60. doi: 10.1186/s10194-021-01239-1.
3
Migraine and neuroinflammation: the inflammasome perspective.
偏头痛与神经炎症:炎症小体的视角。
J Headache Pain. 2021 Jun 10;22(1):55. doi: 10.1186/s10194-021-01271-1.
4
The Role of Metabolism in Migraine Pathophysiology and Susceptibility.代谢在偏头痛病理生理学和易感性中的作用。
Life (Basel). 2021 May 1;11(5):415. doi: 10.3390/life11050415.
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Are 5-HT receptor agonists effective anti-migraine drugs?5-羟色胺受体激动剂是有效的抗偏头痛药物吗?
Expert Opin Pharmacother. 2021 Jul;22(10):1221-1225. doi: 10.1080/14656566.2021.1910235. Epub 2021 Apr 12.
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Tryptophan Metabolism and Gut-Brain Homeostasis.色氨酸代谢与肠道-脑稳态
Int J Mol Sci. 2021 Mar 15;22(6):2973. doi: 10.3390/ijms22062973.
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