Department of Chemical Engineering, Indian Institute of Technology Delhi, New Delhi 110016, India.
Chem Commun (Camb). 2021 Jan 7;57(2):174-186. doi: 10.1039/d0cc06037b. Epub 2020 Dec 11.
Bacterial infection is a major global threat to human health and currently one of the leading causes of death worldwide. The development of probes for rapid diagnosis of bacteria with desired sensitivity and selectivity along with antibacterial activity against multidrug-resistant (MDR) bacteria has remained a great challenge. Whilst the traditional methods such as cell culture and colony counting, polymerase chain reaction and immunoassays are used for bacterial infection detection, these are time consuming, laborious and require a skilled operator. On the other hand, the rapid emergence of MDR bacteria is also posing another serious public health threat. Hence, it is an utmost urgency to develop novel therapeutics and rapid diagnostic agents for tackling MDR bacteria. Over the last few years, significant progress has been made towards the development of metal-based aggregation-induced emission luminogens (AIEgens) for bacterial management. These AIEgen materials offer potential applications for simultaneous detection and image-guided elimination of bacteria for the treatment of bacterial infections. In this Feature Article, we have highlighted the recent progress in the development of metal-based AIEgens for detection, discrimination and decimation of bacteria. In addition, the potential challenges in developing antibacterial agents and several future perspectives of metal-based AIEgens in this field have also been discussed.
细菌感染是对人类健康的重大全球性威胁，目前是全球主要死因之一。开发具有所需灵敏度和选择性的探针，同时对多药耐药（MDR）细菌具有抗菌活性，一直是一个巨大的挑战。虽然细胞培养和菌落计数、聚合酶链反应和免疫测定等传统方法用于细菌感染检测，但这些方法既耗时又费力，并且需要熟练的操作人员。另一方面，MDR 细菌的迅速出现也构成了另一个严重的公共卫生威胁。因此，迫切需要开发新型治疗方法和快速诊断试剂来应对 MDR 细菌。在过去的几年中，在开发用于细菌管理的基于金属的聚集诱导发射发光体（AIEgen）方面取得了重大进展。这些 AIEgen 材料为同时检测和图像引导消除细菌提供了潜在的应用，以治疗细菌感染。在这篇专题文章中，我们强调了开发用于检测、区分和消除细菌的基于金属的 AIEgen 的最新进展。此外，还讨论了开发抗菌剂的潜在挑战以及该领域基于金属的 AIEgen 的几个未来展望。
