Gangaram Serisha, Naidoo Yougasphree, Dewir Yaser Hassan, Singh Moganavelli, Lin Johnson, Murthy Hosakatte Niranjana
School of Life Sciences, Westville Campus, University of KwaZulu-Natal, Private Bag X54001, Durban 4000, South Africa.
Plant Production Department, College of Food and Agriculture Sciences, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi Arabia.
Plants (Basel). 2023 Jun 21;12(13):2396. doi: 10.3390/plants12132396.
(Acanthaceae) is a shrub located in South Africa and is relatively understudied. However, plants within this genus are well known for their medicinal and ethnopharmacological properties. This study aimed to characterise the phytochemical compounds and antibacterial efficacies of . . Phytochemical analysis, fluorescence microscopy and gas chromatography-mass spectrometry (GC-MS) analysis were performed to determine the composition of compounds that may be of medicinal importance. Crude leaf and stem extracts (hexane, chloroform and methanol) were subjected to an antibacterial analysis against several pathogenic microorganisms. The qualitative phytochemical screening of leaf and stem extracts revealed the presence various compounds. Fluorescence microscopy qualitatively assessed the leaf and stem powdered material, which displayed various colours under bright and UV light. GC-MS chromatograms represents 10-108 peaks of various compounds detected in the leaf and stem crude extracts. Major pharmacologically active compounds found in the extracts were alpha-amyrin, flavone, phenol, phytol, phytol acetate, squalene and stigmasterol. Crude extracts positively inhibited Gram-positive and Gram-negative bacteria. Significance was established at < 0.05 for all concentrations and treatments. These results indicate that the leaves and stems of are rich in bioactive compounds, which could be a potential source of antibacterial agents for treating various diseases linked to the pathogenic bacteria studied. Future discoveries from this plant could advance the use of indigenous traditional medicine and provide novel drug leads.
（爵床科）是一种生长在南非的灌木，目前对其研究相对较少。然而，该属植物以其药用和民族药理学特性而闻名。本研究旨在表征……的植物化学化合物和抗菌功效。进行了植物化学分析、荧光显微镜检查和气相色谱 - 质谱联用（GC - MS）分析，以确定可能具有药用价值的化合物组成。对粗制的叶和茎提取物（己烷、氯仿和甲醇）针对几种致病微生物进行了抗菌分析。叶和茎提取物的定性植物化学筛选揭示了多种化合物的存在。荧光显微镜对叶和茎的粉末材料进行了定性评估，其在明亮光和紫外光下呈现出各种颜色。GC - MS色谱图代表了在叶和茎粗提取物中检测到的10 - 108个不同化合物的峰。提取物中发现的主要药理活性化合物有α - 香树脂醇、黄酮、酚、叶绿醇、叶绿醇乙酸酯、角鲨烯和豆甾醇。粗提取物对革兰氏阳性菌和革兰氏阴性菌均有阳性抑制作用。所有浓度和处理的显著性均在<0.05水平确定。这些结果表明，……的叶和茎富含生物活性化合物，这可能是治疗与所研究的致病细菌相关的各种疾病的抗菌剂的潜在来源。对这种植物未来的发现可能会推动本土传统医学的应用，并提供新的药物先导物。
