二甲双胍对多囊卵巢综合征患者体重的影响：基于模型的荟萃分析。
Effects of metformin on body weight in polycystic ovary syndrome patients: model-based meta-analysis.
机构信息
Department of Pharmacy, The People's Hospital of Jiangyin , Jiangyin, China.
Department of Pharmacy, Children's Hospital of Fudan University , Shanghai, China.
出版信息
Expert Rev Clin Pharmacol. 2021 Jan;14(1):121-130. doi: 10.1080/17512433.2021.1863788. Epub 2020 Dec 21.
OBJECTIVES
The present study aimed to investigate the effects of metformin on body weight in polycystic ovary syndrome (PCOS) patients by model-based meta-analysis (MBMA).
METHODS
Randomized controlled trial (RCT) studies of metformin in treatment of PCOS patients were collected and efficacy indicators were the body mass index (BMI) change rates from baseline.
RESULTS
28 RCT studies, 1631 PCOS patients were included for analysis. Model of metformin monotherapy, and model of metformin combination therapy were established, respectively. After deducting control group effects, the E of metformin on BMI were -5.88% and -11.8% in metformin monotherapy and metformin combination therapy, respectively. In order to play better curative effects, for metformin monotherapy, 1000 mg/day metformin needs for at least 25.5 weeks; For metformin combination therapy, 1000 mg/day metformin needs for at least 58.6 weeks.
CONCLUSION
It was the first time to quantify the effects of metformin on body weight and recommend dose and duration for metformin monotherapy and metformin combination therapy in PCOS patients.
目的
本研究旨在通过基于模型的荟萃分析（MBMA）探讨二甲双胍对多囊卵巢综合征（PCOS）患者体重的影响。
方法
收集了二甲双胍治疗 PCOS 患者的随机对照试验（RCT）研究，并将体重指数（BMI）的变化率作为疗效指标。
结果
共纳入 28 项 RCT 研究，1631 例 PCOS 患者进行分析。分别建立了二甲双胍单药治疗模型和二甲双胍联合治疗模型。扣除对照组的影响后，二甲双胍单药治疗和联合治疗对 BMI 的 E 值分别为-5.88%和-11.8%。为了发挥更好的疗效，对于二甲双胍单药治疗，至少需要 25.5 周的 1000mg/天二甲双胍；对于二甲双胍联合治疗，至少需要 58.6 周的 1000mg/天二甲双胍。
结论
这是首次对二甲双胍对体重的影响进行量化，并为 PCOS 患者推荐二甲双胍单药和联合治疗的剂量和疗程。
Zotero 插件