Department of Natural Resources Science, University of Rhode Island, Kingston, United States.
Department of Biology, Sacred Heart University, Fairfield, United States.
Elife. 2020 Dec 11;9:e60626. doi: 10.7554/eLife.60626.
Elite human and animal athletes must acquire the fuels necessary for extreme feats, but also contend with the oxidative damage associated with peak metabolic performance. Here, we show that a migratory bird with fuel stores composed of more omega-6 polyunsaturated fats (PUFA) expended 11% less energy during long-duration (6 hr) flights with no change in oxidative costs; however, this short-term energy savings came at the long-term cost of higher oxidative damage in the omega-6 PUFA-fed birds. Given that fatty acids are primary fuels, key signaling molecules, the building blocks of cell membranes, and that oxidative damage has long-term consequences for health and ageing, the energy savings-oxidative cost trade-off demonstrated here may be fundamentally important for a wide diversity of organisms on earth.
精英人类和动物运动员必须获取极端表现所需的燃料，但也必须应对与峰值代谢表现相关的氧化损伤。在这里，我们展示了一种候鸟，其燃料储备由更多的ω-6 多不饱和脂肪（PUFA）组成，在不改变氧化成本的情况下，长时程（6 小时）飞行中消耗的能量减少了 11%；然而，这种短期的能量节省是以 ω-6 PUFA 喂养的鸟类中更高的氧化损伤为代价的。鉴于脂肪酸是主要燃料、关键信号分子、细胞膜的组成部分，并且氧化损伤对健康和衰老有长期影响，这里展示的能量节省-氧化成本权衡可能对地球上的各种生物都具有重要意义。
