Nutrition Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Int J Food Sci Nutr. 2021 Aug;72(5):632-649. doi: 10.1080/09637486.2020.1857710. Epub 2020 Dec 12.
The aim of this systematic review and meta-analysis was to evaluate the effect of probiotics, parabiotics, synbiotics, fermented foods and other microbial forms on immunoglobulin production. We searched PubMed, Scopus, Web of Science, National Institute of Health Clinical Trials Register, and Cochrane Central Register of Clinical Trials, up to February 2020. All clinical trials that investigated the effects of oral intake of probiotics, parabiotics, synbiotics, fermented foods and other microbial forms on immunoglobulin (Ig)A, IgE, Japanese cedar pollen (JCP)-specific IgE, IgG, and IgM, for a duration of >7 days were included. Fifty-nine studies met the inclusion criteria, of these 54 studies were included in the analysis. The results indicated a significant increase in salivary IgA secretion rate (SMD = 0.21, 95% CI 0.02-0.39), while no significant effect was observed on other Igs. In conclusion, mentioned supplementation induced a small but significant effect on salivary secretion rate of IgA.
本系统评价和荟萃分析的目的是评估益生菌、副益生菌、合生菌、发酵食品和其他微生物形式对免疫球蛋白产生的影响。我们检索了 PubMed、Scopus、Web of Science、美国国立卫生研究院临床试验注册处和 Cochrane 临床试验中心注册库，截至 2020 年 2 月。所有纳入的临床试验均为口服摄入益生菌、副益生菌、合生菌、发酵食品和其他微生物形式对免疫球蛋白（Ig）A、IgE、日本扁柏花粉（JCP）特异性 IgE、IgG 和 IgM 影响的研究，持续时间>7 天。符合纳入标准的研究有 59 项，其中 54 项研究纳入分析。结果表明唾液分泌型免疫球蛋白 A 分泌率（SMD=0.21，95%CI0.02-0.39）有显著增加，而其他免疫球蛋白则无显著影响。总之，上述补充剂对分泌型 IgA 的唾液分泌率有较小但显著的影响。
