Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, No. 180, Fenglin Road, Shanghai, 200032, China.
Cancer Imaging. 2020 Dec 12;20(1):87. doi: 10.1186/s40644-020-00363-6.
The computed tomography (CT) characteristic of ground glass opacity (GGO) were shown to be associated with clinical significance in lung adenocarcinoma. We evaluated the prognostic value of the solid component ratio of GGO IA invasive lung adenocarcinoma.
We retrospectively analyzed the records of GGO IA patients who received surgical resection from April 2012 to December 2015. The solid component ratio was calculated based on thin-slice CT scans. Baseline features were compared stratified by the ratio. Cox proportional hazard models and survival analyses were adopted to explore potential prognostic value regarding overall survival (OS) and disease-free survival (DFS).
Four hundred fifteen patients were included. The higher ratio was significantly associated with larger tumor diameter, pathological subtypes and choice of surgical type. There was a significantly worse DFS with a > 50% ratio. The subgroups of 0% and ≤ 50% ratio showed close survival curves of DFS. Similar trends were observed in OS. Multivariate analyses revealed that the ratio was a significant predictor for DFS, but not for OS. No significant prognostic difference was observed between lobectomy and limited resections.
A higher solid component ratio may help to predict a significantly worse prognosis of GGO IA lung adenocarcinoma.
计算机断层扫描（CT）显示磨玻璃密度（GGO）特征与肺腺癌的临床意义相关。我们评估了 GGOIA 浸润性肺腺癌中实性成分比例的预后价值。
我们回顾性分析了 2012 年 4 月至 2015 年 12 月接受手术切除的 GGOIA 患者的记录。根据薄层 CT 扫描计算实性成分比。根据该比例对基线特征进行分层比较。采用 Cox 比例风险模型和生存分析探讨整体生存（OS）和无病生存（DFS）的潜在预后价值。
共纳入 415 例患者。较高的比例与更大的肿瘤直径、病理亚型和手术类型选择显著相关。>50%比例的 DFS 显著更差。0%和≤50%比例亚组的 DFS 生存曲线接近。OS 也呈现出类似的趋势。多因素分析显示，该比例是 DFS 的显著预测因素，但不是 OS 的预测因素。肺叶切除术和局限性切除术之间未观察到显著的预后差异。
较高的实性成分比例可能有助于预测 GGOIA 肺腺癌的预后显著恶化。
