Department of Community Health Sciences, University of Calgary, Calgary, AB.
Department of Community Health Sciences, University of Calgary, Calgary, AB; Department of Pediatrics, University of Calgary, Calgary, AB.
J Obstet Gynaecol Can. 2021 May;43(5):589-595. doi: 10.1016/j.jogc.2020.09.024. Epub 2020 Nov 5.
Rapid repeat pregnancy (RRP), a birth occurring within 33 months of a previous birth, is associated with adverse neonatal outcomes. RRP occurs among 25%-35% of adolescents who become pregnant. The current study examines trends in and outcomes of adolescent RRP in the Canadian context.
Using population-based data from the Discharge Abstract Database, we linked maternal and newborn records from labour and delivery hospitalizations across Canada (excluding Québec) from fiscal years 2004/2005 to 2014/2015. Women were included if they were aged younger than 20 years at the index birth event and delivered an infant during the study period. We assessed absolute rates of RRP and differences between groups using χ tests. Linear tests for trend assessed change over time. Conditional logistic regression models assessed odds of adverse maternal and neonatal outcomes in RRPs compared with first pregnancies.
Overall, we captured 67 957 adolescent pregnancies during the study period. Of these, 32.9% (95% CI 32.5%-33.2%) had an RRP. Rates of RRP were higher among 18- to 19-year-olds (34.1%; 95% CI 33.6%-34.5%) than 15- to 17-year-olds (30.4%; 95% CI 29.7%-31.0%). There was substantial variation in RRP rates across provinces and territories, from 24.5% (95% CI 23.6%-35.6%) in British Columbia to 47.3% (95% CI 46.1%-48.4%) in Manitoba. Generally, the odds of maternal or neonatal morbidity were similar in second pregnancies. However, adolescents had decreased odds of having a small-for-gestational-age infant in their second pregnancy (P < 0.001), affecting 0.4% (95% CI 0.3%-0.7%) of second pregnancies.
Adolescents who experience a pregnancy are at high risk of experiencing an RRP; however, odds of maternal and neonatal morbidity were similar in second and first pregnancies.
快速重复妊娠(RRP)是指在前一次分娩后 33 个月内再次分娩,与新生儿不良结局有关。RRP 发生在 25%-35%的青少年怀孕者中。本研究在加拿大背景下调查青少年 RRP 的趋势和结局。
利用来自加拿大(魁北克除外)分娩住院人口基础数据,我们从 2004/2005 财政年度至 2014/2015 财政年度的劳动和分娩医院记录中链接产妇和新生儿记录。索引分娩事件时年龄小于 20 岁并在研究期间分娩的女性被纳入研究。我们使用 χ 检验评估 RRP 的绝对发生率和组间差异。线性趋势检验评估随时间的变化。条件逻辑回归模型评估 RRPs 与首次妊娠相比不良母婴结局的可能性。
在研究期间,我们共捕获了 67957 例青少年妊娠。其中,32.9%(95%置信区间 32.5%-33.2%)为 RRP。18-19 岁(34.1%;95%置信区间 33.6%-34.5%)RRP 发生率高于 15-17 岁(30.4%;95%置信区间 29.7%-31.0%)。各省和地区之间 RRP 发生率差异很大,从不列颠哥伦比亚省的 24.5%(95%置信区间 23.6%-35.6%)到马尼托巴省的 47.3%(95%置信区间 46.1%-48.4%)。通常情况下,第二次妊娠时母婴发病率的可能性相似。然而,青少年在第二次妊娠中发生小于胎龄儿的可能性较低(P < 0.001),占第二次妊娠的 0.4%(95%置信区间 0.3%-0.7%)。
经历过妊娠的青少年再次妊娠时发生 RRP 的风险很高;然而,第二次和第一次妊娠时母婴发病率的可能性相似。