Stewart T B, Bidner T D, Southern L L, Simmons L A
Am J Vet Res. 1984 May;45(5):984-6.
Twenty-four weanling crossbred pigs were inoculated with 10,000 embryonated Ascaris suum eggs. The infection was aborted in 1 group (n = 8 pigs) with fenbendazole (3 mg/kg of body weight) given on postinfection days 2, 3, and 4 and in a 2nd group (n = 8 pigs) given fenbendazole at the same rate on postinfection days 6, 7, and 8; a 3rd group (n = 8 pigs) was not treated with fenbendazole. All pigs were necropsied at 24 days after they were inoculated. Fenbendazole was 99% effective against A suum larvae in the 2 treated groups. Early treated pigs had significantly higher daily weight gains (P less than 0.05) and were 22% more efficient in feed conversion than were nontreated pigs. Lung weights increased linearly with length of exposure to migrating A suum larvae (P less than 0.10). Liver weights were greater in treated pigs than in non-treated pigs (P less than 0.01). A negative correlation existed between number of liver lesions and liver weights of all pigs (P less than 0.05).
给24头断奶的杂种猪接种10000枚猪蛔虫感染性虫卵。在感染后的第2、3和4天，给一组（n = 8头猪）投喂芬苯达唑（3毫克/千克体重），另一组（n = 8头猪）在感染后的第6、7和8天以相同剂量投喂芬苯达唑，从而使这两组猪的感染中止；第三组（n = 8头猪）不进行芬苯达唑治疗。所有猪在接种后24天进行剖检。在两个治疗组中，芬苯达唑对猪蛔虫幼虫的疗效达99%。早期接受治疗的猪日增重显著更高（P < 0.05），饲料转化率比未治疗的猪高22%。肺脏重量随着暴露于迁移的猪蛔虫幼虫的时间延长而呈线性增加（P < 0.10）。治疗组猪的肝脏重量大于未治疗组猪（P < 0.01）。所有猪的肝脏病变数量与肝脏重量之间存在负相关（P < 0.05）。
