Yakymchuk Оlexander М, Klishch Іvan М, Boychuk Alla V, Yakymchuk Yuliia В
I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY, TERNOPIL, UKRAINE.
Wiad Lek. 2020;73(10):2224-2226.
The aim: To determine the features of endogenous intoxication in the blood of experimental animals in the setting of simulated hyperthyroidism under the influence of various anesthetics.
Materials and methods: Rats were injected L-thyroxine to simulate hyperthyroidism, and sodium thiopental and dexmedetomidine in the setting of euthyroidism and hyperthyroidism.
Results: An increase in the activity of endogenous intoxication, the content of medium-molecular peptides (MMW1, MMW2) and their coefficient (K = MSM2 / MSM1) were observed in the erythrocytes of experimental animals with hyperthyroidism. A significant difference in the rates of endogenous intoxication with the use of sodium thiopental and dexmedetomidine hydrochloride in the setting of euthyroidism and hyperthyroidism has been determined.
Conclusions: In experimental hyperthyroidism in rats, an increase in the level of endogenous intoxication has been determined, which is indicated by an increase in the permeability of erythrocyte membranes and an increase in the level of macromolecular fractions of medium-weight molecules in the blood.The use of sodium thiopental and dexmedetomidine in the setting of euthyroidism and hyperthyroidism is accompanied by pronounced changes in the body of experimental animals, namely: increased endogenous intoxication, which deepens the destructive changes in the organs and systems of experimental animals.
确定在各种麻醉剂影响下，实验动物模拟甲状腺功能亢进时血液中内源性中毒的特征。
材料与方法：给大鼠注射L-甲状腺素以模拟甲状腺功能亢进，并在甲状腺功能正常和甲状腺功能亢进状态下分别注射硫喷妥钠和右美托咪定。
结果：在甲状腺功能亢进的实验动物红细胞中，观察到内源性中毒活性增加、中分子肽（MMW1、MMW2）含量及其系数（K = MSM2 / MSM1）升高。已确定在甲状腺功能正常和甲状腺功能亢进状态下使用硫喷妥钠和盐酸右美托咪定后内源性中毒速率存在显著差异。
结论：在大鼠实验性甲状腺功能亢进中，已确定内源性中毒水平升高，这表现为红细胞膜通透性增加以及血液中中分子量分子的大分子组分水平升高。在甲状腺功能正常和甲状腺功能亢进状态下使用硫喷妥钠和右美托咪定伴随着实验动物体内明显变化，即：内源性中毒增加，这加深了实验动物器官和系统的破坏性变化。
