Ahn Dong-Won, Jeong Ji Bong, Kang Jinwoo, Kim Su Hwan, Kim Ji Won, Kim Byeong Gwan, Lee Kook Lae, Oh Sohee, Yoon Soon Ho, Park Sang Joon, Lee Doo Hee
Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, South Korea.
Department of Biostatistics, Medical Research Collaborating Center, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul 07061, South Korea.
World J Gastroenterol. 2020 Nov 28;26(44):6979-6992. doi: 10.3748/wjg.v26.i44.6979.
Gallbladder polyps (GBPs) are known to be associated with obesity and metabolic diseases. However, to date, the relationship between GBPs and abnormal body fat distribution, such as fatty liver, visceral obesity, or sarcopenia, has not yet been established.
To evaluate whether GBPs are associated with fatty liver, visceral obesity, or sarcopenia.
We retrospectively reviewed the medical records of subjects who underwent various laboratory tests, body composition measurement with a non-invasive body composition analyzer, and abdominal ultrasonography during health checkups. A total of 1405 subjects with GBPs were compared with 2810 age- and sex-matched controls.
The mean age of the subjects was 46.8 ± 11.7 years, and 63.8% were male. According to multiple logistic regression analysis, the presence of fatty liver [odds ratio (OR) 1.413; 95% confidence interval (CI) 1.218-1.638; < 0.001] was an independent risk factor for GBP, together with low levels of alanine aminotransferase (OR 0.993; 95%CI 0.989-0.996; < 0.001). Additionally, fatty liver showed both independent (OR 1.629; 95%CI, 1.335-1.988; < 0.001) and dose-dependent (moderate to severe fatty liver; OR 2.137; 95%CI, 1.662-2.749; < 0.001) relationship with large GBPs (≥ 5 mm). The presence of sarcopenia and high visceral fat area were not significantly associated with GBPs.
Fatty liver was found to be closely associated with GBPs irrespective of sarcopenia and visceral obesity.
已知胆囊息肉（GBP）与肥胖和代谢性疾病有关。然而，迄今为止，GBP与异常体脂分布（如脂肪肝、内脏肥胖或肌肉减少症）之间的关系尚未确立。
评估GBP是否与脂肪肝、内脏肥胖或肌肉减少症有关。
我们回顾性分析了在健康体检期间接受各种实验室检查、使用无创身体成分分析仪进行身体成分测量以及腹部超声检查的受试者的病历。将1405例患有GBP的受试者与2810例年龄和性别匹配的对照进行比较。
受试者的平均年龄为46.8±11.7岁，63.8%为男性。根据多因素logistic回归分析，脂肪肝的存在[比值比（OR）1.413；95%置信区间（CI）1.218 - 1.638；P < 0.001]是GBP的独立危险因素，同时丙氨酸转氨酶水平低（OR 0.993；95%CI 0.989 - 0.996；P < 0.001）也是。此外，脂肪肝与大的GBP（≥5 mm）显示出独立（OR 1.629；95%CI 1.335 - 1.988；P < 0.001）和剂量依赖性（中度至重度脂肪肝；OR 2.137；95%CI 1.662 - 2.749；P < 0.001）关系。肌肉减少症的存在和高内脏脂肪面积与GBP无显著相关性。
发现脂肪肝与GBP密切相关，与肌肉减少症和内脏肥胖无关。
Zotero 插件
