回顾米替福新的作用并建议将其用于治疗冠状病毒病（COVID-19）。
Reviewing the Effects of Miltefosine and Suggesting It for the Treatment of Coronavirus Disease (COVID-19).
作者信息
Latifi Alireza
机构信息
School of Public Health, Department of Medical Parasitology and Mycology, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Infect Dis (Auckl). 2020 Dec 1;13:1178633720977488. doi: 10.1177/1178633720977488. eCollection 2020.
OBJECTIVE
Miltefosine is an anti-cancer drug used to treat leishmaniasis and deadly opportunistic free-living amoeba and other deadly pathogenic microorganisms. Several studies have demonstrated its antiviral effect. In this study, we discuss the effectiveness of this drug on pathogenic microorganisms, and according to the functional system of the medicine, we present this drug as a therapeutic proposal to treat Coronavirus disease (COVID-19).
METHODS
A literature search was conducted in electronic databases, including Pubmed, Science Direct, Elsevier, and Google Scholar, and articles published from 2006 to 2020 (the last decade) were selected. The search keywords included Miltefosine, microorganism, pathogen, and treatment.
RESULTS
The studies indicated that Miltefosine had therapeutic effects on leishmaniasis and deadly opportunistic free-living amoeba and other deadly pathogenic microorganisms. Several studies have proven its antiviral effect.
CONCLUSION
Owing to the beneficial effects of this drug on pathogenic and deadly microorganisms and antiviral effects, and due to the epidemic of Coronavirus and the lack of effective treatment and vaccine, this drug is recommended as one of the treatment options for this disease.
目的
米替福新是一种抗癌药物，用于治疗利什曼病、致命的机会性自由生活阿米巴及其他致命致病微生物。多项研究已证实其具有抗病毒作用。在本研究中，我们探讨了该药物对致病微生物的有效性，并根据药物的功能体系，将其作为治疗冠状病毒病（COVID-19）的一种治疗方案提出。
方法
在电子数据库中进行文献检索，包括PubMed、Science Direct、爱思唯尔和谷歌学术，选取2006年至2020年（过去十年）发表的文章。检索关键词包括米替福新、微生物、病原体和治疗。
结果
研究表明，米替福新对利什曼病、致命的机会性自由生活阿米巴及其他致命致病微生物具有治疗作用。多项研究已证实其抗病毒作用。
结论
由于该药物对致病和致命微生物具有有益作用以及抗病毒作用，且鉴于冠状病毒的流行以及缺乏有效的治疗方法和疫苗，推荐将该药物作为该病的治疗选择之一。
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