mTOR 抑制剂在 COVID-19 中的应用：对 RNA 病毒疗效的评论和综述。
mTOR inhibition in COVID-19: A commentary and review of efficacy in RNA viruses.
机构信息
Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Division of General Internal Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
出版信息
J Med Virol. 2021 Apr;93(4):1843-1846. doi: 10.1002/jmv.26728. Epub 2020 Dec 17.
Abstract
In this commentary, we shed light on the role of the mammalian target of rapamycin (mTOR) pathway in viral infections. The mTOR pathway has been demonstrated to be modulated in numerous RNA viruses. Frequently, inhibiting mTOR results in suppression of virus growth and replication. Recent evidence points towards modulation of mTOR in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We discuss the current literature on mTOR in SARS-CoV-2 and highlight evidence in support of a role for mTOR inhibitors in the treatment of coronavirus disease 2019.
摘要
在这篇评论中，我们探讨了雷帕霉素靶蛋白（mTOR）途径在病毒感染中的作用。研究表明，mTOR 途径在多种 RNA 病毒中受到调节。通常，抑制 mTOR 会导致病毒生长和复制受到抑制。最近的证据表明，mTOR 在严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染中受到调节。我们讨论了关于 SARS-CoV-2 中 mTOR 的现有文献，并强调了支持使用 mTOR 抑制剂治疗 2019 年冠状病毒病的证据。
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