Department of Dermatology, Kerman University of Medical Sciences, Kerman, Iran.
Dermatol Ther. 2021 Jan;34(1):e14671. doi: 10.1111/dth.14671. Epub 2020 Dec 29.
Traditional treatment modalities for wart require long-term treatment course and usually have high recurrence rates and unwanted side effects. In this review article, we evaluated different types of laser therapy in the treatment of warts. Published articles since 2000 up to July 2020 about laser therapy in genital and non-genital warts were searched and assessed. Fifty articles were selected for the final review, including 22 pulsed dye laser (PDL), 10 neodymium-yttrium-aluminum-garnet (Nd: YAG), 3 erbium-doped yttrium-aluminum-garnet (Er: YAG), 14 carbon dioxide (CO ) laser and one systematic review. Complete response rates were different in terms of laser type used (0%-100%, 9.1%-100%, 83.3%-100%, and 59.15%-100% for PDL, Nd: YAG, Er: YAG, and CO laser, respectively). There was no significant difference between conventional treatment modalities and laser therapy regarding efficacy and recurrence rate. Combination of lasers with keratolytic agents, immunomodulators and photodynamic therapy can be helpful especially in immunosuppressed patients, refractory, and recurrent lesions. PDL has the lowest occurrence of adverse effects relative to other types of lasers.
传统的疣治疗方法需要长期治疗，且通常复发率高，副作用多。在这篇综述文章中，我们评估了不同类型的激光疗法在疣治疗中的应用。检索并评估了 2000 年至 2020 年 7 月期间发表的关于生殖器和非生殖器疣激光治疗的文章。最终有 50 篇文章被纳入综述，其中包括 22 篇脉冲染料激光（PDL）、10 篇钕钇铝石榴石（Nd: YAG）、3 篇掺铒钇铝石榴石（Er: YAG）、14 篇二氧化碳（CO ）激光和一篇系统评价。不同激光类型的完全应答率有所不同（PDL、Nd: YAG、Er: YAG 和 CO 激光分别为 0%-100%、9.1%-100%、83.3%-100%和 59.15%-100%）。在疗效和复发率方面，传统治疗方法与激光治疗无显著差异。联合使用角质松解剂、免疫调节剂和光动力疗法的激光治疗，对免疫抑制患者、难治性和复发性病变尤其有益。与其他类型的激光相比，PDL 不良反应发生率最低。
