Head of Dermatology and Laser Department, College of Medicine, University of Kufa, Najaf, Iraq.
Imam AlHassan Almujtaba Teaching Hospital, Karbala Health Directorate, Karbala, Iraq.
Skin Res Technol. 2023 Sep;29(9):e13462. doi: 10.1111/srt.13462.
Warts are one of the contagious viral diseases that may cause disturbing cosmetic problems. Plane warts represents a common self-limiting viral infection of the skin caused by the Human Papilloma Virus, however, those that do not disappear by themselves can be very difficult to treat with no uniformly effective treatment modality.
To assess the efficacy of long pulsed 532 nm ND:YAG laser in the treatment of plane warts.
In this therapeutic clinical trial study, 34 patients with plane warts were enrolled. Each patient was eligible for up to three treatment sessions administrated at 2 weeks intervals with long pulsed ND:YAG laser at a spot size 3 mm; wavelength 532 nm; pulsed duration 20 ms; and fluence 30 J/cm . The patients were assessed before each treatment session and at 3 months after the last treatment session. The response to treatment was graded using four points scale: Scale 1 = poor: <25%, Scale 2 = fair: 25%-50%, Scale 3 = good: 51%-75%, Scale 4 = excellent: >75%.
Twenty-two patients only with a total of 478 lesions, completed the study; their ages ranged from (6-45) years with a mean ± SD 19.95 ± 13.142 years. Thirteen patients (59.09%) were female and nine (40.90%) were male. The results from this study showing that long pulsed ND:YAG laser 532 nm led to an excellent response in 19 patients (86.36%) in which 15 of 19 patients showed a complete response (78.94%); one patient showed a good response (4.545%), one showed a fair response (4.545%) and one showed a poor response (4.545%) at the end of three-months follow up. The difference was statistically significant; the P value at the three months follow-up was 0.002. The cumulative clearance rate after the first, second, and third treatment sessions was 58.4%, 77.7%, and 89.9% respectively. Recurrence was seen in only one patient (4.545%). Side effects were generally mild and didn't prevent normal activity.
Long pulsed ND:YAG laser 532 nm appears to be an effective method for treatment of plane warts.
疣是一种传染性病毒性疾病，可能导致令人困扰的美容问题。扁平疣是一种由人乳头瘤病毒引起的常见、自限性皮肤病毒感染，但那些不能自行消失的扁平疣治疗起来非常困难，目前尚无统一有效的治疗方法。
评估长脉冲 532nmND:YAG 激光治疗扁平疣的疗效。
在这项治疗性临床试验研究中，纳入了 34 名扁平疣患者。每位患者最多可接受 3 次治疗，间隔 2 周，使用长脉冲 ND:YAG 激光，光斑大小 3mm；波长 532nm；脉冲持续时间 20ms；能量密度 30J/cm。在每次治疗前和最后一次治疗后 3 个月对患者进行评估。采用 4 分制评分评估治疗反应：1 分=差：<25%，2 分=一般：25%-50%，3 分=好：51%-75%，4 分=优：>75%。
22 名患者（共 478 处皮损）完成了研究；年龄 6-45 岁，平均（19.95±13.142）岁。13 名患者（59.09%）为女性，9 名（40.90%）为男性。本研究结果显示，长脉冲 ND:YAG 激光 532nm 导致 19 名患者（86.36%）获得优异疗效，其中 15 名患者（78.94%）完全缓解；1 名患者（4.545%）反应良好，1 名患者（4.545%）反应一般，1 名患者（4.545%）反应较差，在 3 个月随访时。差异具有统计学意义，P 值在 3 个月随访时为 0.002。第 1、2 和第 3 次治疗后的累积清除率分别为 58.4%、77.7%和 89.9%。仅 1 名患者（4.545%）复发。不良反应一般较轻，不影响正常活动。
长脉冲 ND:YAG 激光 532nm 似乎是治疗扁平疣的有效方法。
