Section of Dermatology, Department of Surgery and Translational Medicine, University of Florence, Firenze, Italy.
Section of Dermatology, Department of Health Sciences, University of Florence, Firenze, Italy.
Skin Res Technol. 2023 Sep;29(9):e13460. doi: 10.1111/srt.13460.
Viral warts, induced by infection by different HPV genotypes, are highly frequent in the general population, particularly during infancy and among adolescents. The effectiveness of the 595 nm Pulse dye-laser in treating viral warts on the hands and feet in both adults and children was investigated in this study.
A selection of 203 patients with multiple viral warts was made. All patients underwent 4-5 treatment sessions with a 595 nm pulse Dye Laser (PDL). Treatment outcome was assessed by a quartile scale: 1 indicates no or low results (0%-25% of the lesion area cleared), 2 indicates slight clearance (25%-50% of the lesion area cleared), 3 indicates moderate-good clearance (50%-75%), and 4 indicates excellent clearance (75%-100%). Patients were asked for a subjective evaluation of the perceived overall results by means of the following score: unsatisfied (1), not very satisfied (2), satisfied (3), and very satisfied (4). Possible side effects were monitored. Results obtained were judged with a photographic evaluation, immediately and at the control visit (6 months after the last laser session).
All patients observed global improvements. Most of the lesions were completely removed after laser therapy. A total of 95% of patients achieved excellent clearance and they were very satisfied following the laser treatment. Relevant side effects were absent in all patients.
PDL treatment with the study device using a wavelength of 595 nm has proven to be a tolerable and safe therapy for viral warts management.
由不同 HPV 基因型感染引起的病毒性疣在普通人群中非常常见,尤其是在婴儿期和青少年期。本研究旨在探讨 595nm 脉冲染料激光治疗手部和足部病毒性疣在成人和儿童中的疗效。
选择了 203 例多发性病毒性疣患者。所有患者均接受 4-5 次 595nm 脉冲染料激光(PDL)治疗。采用四分位尺度评估治疗效果:1 表示无或低效果(病变面积清除率为 0%-25%),2 表示轻微清除(病变面积清除率为 25%-50%),3 表示中度-良好清除(病变面积清除率为 50%-75%),4 表示极好清除(病变面积清除率为 75%-100%)。通过以下评分询问患者对整体治疗效果的主观评价:不满意(1),不太满意(2),满意(3),非常满意(4)。监测可能出现的不良反应。即刻和(最后一次激光治疗后 6 个月的)随访时,通过拍照评估获得治疗结果。
所有患者均观察到整体改善。激光治疗后大多数病变完全消除。95%的患者获得了极好的清除效果,并且对激光治疗非常满意。所有患者均未出现明显不良反应。
使用波长为 595nm 的研究设备进行 PDL 治疗已被证明是一种可耐受且安全的病毒性疣治疗方法。