Department of Pathology & Key Laboratory for Xinjiang Endemic & Ethnic Diseases (Ministry of Education) /Department of Pathology, the First Affiliated Hospital, Shihezi University School of Medicine, Xinjiang, 832000, China.
Department of Obstetrics & Gynecology, the First Affiliated Hospital, Shihezi University School of Medicine, Xinjiang, 832000, China.
Biomark Med. 2021 Jan;15(1):57-67. doi: 10.2217/bmm-2020-0629. Epub 2020 Dec 14.
The aim is to study ANXA2 biomarkers for early diagnosis of cervical cancer. The study used bioinformatics analysis and experimental verification of expression in cervical cancer. expression was higher in cancer tissues than in non-cancer tissues (p = 0.002). was expressed in cell membranes of non-cancer tissues, whereas in cancer tissues it was expressed in both the cell membranes and the cytoplasm. Moreover, expression was more pronounced in squamous cell carcinomas. expression decreased overall survival of patients, and the data suggested that protein expression was associated with invasion and migration of tumors. has high specificity and sensitivity as a detection marker for cervical cancer and can assist in the diagnosis of cervical cancer.
目的是研究 ANXA2 生物标志物用于宫颈癌的早期诊断。本研究采用生物信息学分析和宫颈癌表达的实验验证。结果显示，在癌症组织中表达高于非癌症组织（p=0.002）。在非癌症组织的细胞膜中表达，而在癌症组织中则同时在细胞膜和细胞质中表达。此外，在鳞状细胞癌中表达更为明显。的表达降低了患者的总体生存率，数据表明蛋白表达与肿瘤的侵袭和迁移有关。作为宫颈癌的检测标志物，具有较高的特异性和敏感性，可辅助宫颈癌的诊断。
