Meta 分析核酸扩增检测技术诊断腹部结核的准确性：研究方案。
Meta-analysis of diagnostic accuracy of nucleic acid amplification tests for abdominal tuberculosis: A protocol.
机构信息
Zhejiang Tuberculosis Diagnosis and Treatment Center, Zhejiang Chinese Medicine and Western Medicine Integrated Hospital, Hangzhou, Zhejiang, China.
出版信息
PLoS One. 2020 Dec 14;15(12):e0243765. doi: 10.1371/journal.pone.0243765. eCollection 2020.
BACKGROUND
Abdominal tuberculosis is a severe extrapulmonary tuberculosis, which can lead to serious complications. Early diagnosis and treatment are very important for the prognosis and the diagnosis of abdominal tuberculosis is still difficult. This study aims to evaluate the diagnostic accuracy of nucleic acid amplification tests (NAATs) for abdominal tuberculosis using meta-analysis method.
METHODS
We will search PubMed, the Cochrane Library, Embase, China National Knowledge Infrastructure, and the Wanfang database for studies evaluating the diagnostic accuracy of NAATs for abdominal tuberculosis until May 2020. We will include a systematic review and meta-analysis that evaluated the accuracy of NAATs for abdominal tuberculosis. Any types of study design with full text will be sought and included. The risk of bias will be assessed using the Quality Assessment of Diagnostic Accuracy Studies tool. Stata version 15.0 with the midas command packages will be used to carry out meta-analyses.
RESULTS
The results will provide clinical evidence for diagnostic accuracy of NAATs for abdominal tuberculosis, and this systematic review and meta-analysis will be submitted to a peer-reviewed journal for publication.
CONCLUSION
This overview will provide evidence of NAATs for diagnosis of abdominal tuberculosis.
SYSTEMATIC REVIEW REGISTRATION
INPLASY202060030.
背景
腹部结核是一种严重的肺外结核，可导致严重的并发症。早期诊断和治疗对预后非常重要，而腹部结核的诊断仍然具有挑战性。本研究旨在使用荟萃分析方法评估核酸扩增检测（NAATs）对腹部结核的诊断准确性。
方法
我们将检索 PubMed、Cochrane 图书馆、Embase、中国国家知识基础设施和万方数据库，以获取评估 NAATs 对腹部结核诊断准确性的研究，检索时间截至 2020 年 5 月。我们将纳入系统评价和荟萃分析，评估 NAATs 对腹部结核的准确性。将寻找并纳入任何类型的具有全文的研究设计。使用 Quality Assessment of Diagnostic Accuracy Studies 工具评估偏倚风险。使用 Stata 版本 15.0 和 midas 命令包进行荟萃分析。
结果
研究结果将为 NAATs 对腹部结核的诊断准确性提供临床证据，本系统评价和荟萃分析将提交给同行评议期刊发表。
结论
本综述将为腹部结核的诊断提供 NAATs 的证据。
系统评价注册
INPLASY202060030。
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