Xpert MTB/RIF assay 对结核性心包炎的诊断准确性：系统评价和荟萃分析方案。
Diagnostic accuracy of the Xpert MTB/RIF assay for tuberculous pericarditis: A protocol of systematic review and meta-analysis.
机构信息
Department of Thoracic Surgery, Zhejiang Chinese Medicine and Western Medicine Integrated Hospital, Zhejiang, China.
Zhejiang Tuberculosis Diagnosis and Treatment Center, Zhejiang Chinese Medicine and Western Medicine Integrated Hospital, Zhejiang, China.
出版信息
PLoS One. 2021 May 26;16(5):e0252109. doi: 10.1371/journal.pone.0252109. eCollection 2021.
BACKGROUND
Tuberculous pericarditis (TBP) can lead to serious consequences. Early diagnosis and treatment are very important for TBP, but early diagnosis is still very challenging. This study aims to evaluate the diagnostic accuracy of Xpert MTB/RIF for TBP using meta-analysis method.
METHODS
We will search Embase, PubMed, the Cochrane Library, China National Knowledge Infrastructure (CNKI), and the Wanfang database for researches assessing the diagnostic accuracy of Xpert MTB/RIF for TBP until April 2021. Any types of study design with full text will be selected and included. The Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool will be used to assess the risk of bias. We will use version 15.0 of the STATA software with the midas command packages to carry out meta-analyses.
RESULTS
Evidence for diagnostic accuracy of Xpert MTB/RIF for TBP will be provided through the study, and this protocol will be submitted to a peer-reviewed journal for publication.
CONCLUSION
This study will provide evidence of Xpert MTB/RIF for TBP.
背景
结核性心包炎（TBP）可导致严重后果。早期诊断和治疗对 TBP 非常重要，但早期诊断仍然极具挑战性。本研究旨在使用荟萃分析方法评估 Xpert MTB/RIF 对 TBP 的诊断准确性。
方法
我们将检索 Embase、PubMed、Cochrane 图书馆、中国知网（CNKI）和万方数据库，以获取截至 2021 年 4 月评估 Xpert MTB/RIF 对 TBP 的诊断准确性的研究。选择并纳入任何类型的具有全文的研究设计。将使用 QUADAS-2 工具评估偏倚风险。我们将使用 STATA 软件 15.0 版本和 midas 命令包进行荟萃分析。
结果
本研究将通过研究提供 Xpert MTB/RIF 对 TBP 的诊断准确性证据，并将本方案提交给同行评议期刊发表。
结论
本研究将为 Xpert MTB/RIF 对 TBP 的诊断提供证据。
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