Department of Animal Physiology, Biochemistry and Biostructure, Poznan University of Life Sciences, Poznan, Poland.
J Physiol Pharmacol. 2020 Aug;71(4). doi: 10.26402/jpp.2020.4.13. Epub 2020 Dec 12.
Resveratrol (3, 5, 3'-trihydroxystilbene) is a naturally-occurring, biologically active compound having numerous beneficial effects in the organism, including anti-diabetic properties. Its anti-diabetic action have been relatively well established using various animal models, however, in Goto-Kakizaki (GK) rats is poorly explored. These animals are non-obese and have a congenital type 2 diabetes. In the present study, effects of resveratrol on cholesterol content, blood levels of some hormones (thyroxine, triiodothyronine, ghrelin and spexin), glucose and parameters indirectly related with renal function (creatinine, urea nitrogen, total protein and albumin) were explored in GK rats. GK and control rats were treated with resveratrol for 10 weeks at the dose of 20 mg/kg body weight. It was shown that cholesterol content was significantly increased in the blood, liver and the skeletal muscle of diabetic rats, compared with the control animals. However, the resveratrol therapy was associated with a markedly reduced tissue cholesterol content. Our study also demonstrated that blood levels of thyroxine (T4) were decreased, and triiodothyronine (T3) increased in GK rats. These alterations were, however, not significantly affected by resveratrol. GK rats had elevated blood glucose levels, but hyperglycemia was not ameliorated by resveratrol. It was also shown that blood creatinine levels were increased in diabetic rats. However, in animals subjected to the resveratrol therapy, the blood creatinine level was unchanged. Concentrations of ghrelin, spexin and other blood parameters indirectly related with the renal function were shown to be similar in GK and control rats. These results indicate that resveratrol beneficially influences cholesterol concentrations in tissues of diabetic rats; however, it is ineffective in the case of thyroid hormones and glucose. Moreover, it was shown that resveratrol did not induce any significant effects in non-diabetic animals.
白藜芦醇（3,5,3'-三羟基二苯乙烯）是一种天然存在的、具有生物活性的化合物，在生物体中具有许多有益的作用，包括抗糖尿病特性。它的抗糖尿病作用已在各种动物模型中得到了相对较好的确立，然而，在 GK 大鼠中研究甚少。这些动物不肥胖，患有先天性 2 型糖尿病。在本研究中，研究了白藜芦醇对胆固醇含量、某些激素（甲状腺素、三碘甲状腺原氨酸、胃饥饿素和 Spexin）、血糖以及与肾功能间接相关的参数（肌酐、尿素氮、总蛋白和白蛋白）的影响在 GK 大鼠中。GK 和对照组大鼠用 20mg/kg 体重的白藜芦醇治疗 10 周。结果表明，与对照组动物相比，糖尿病大鼠的血液、肝脏和骨骼肌中的胆固醇含量显著增加。然而，白藜芦醇治疗与组织胆固醇含量的显著降低有关。我们的研究还表明，GK 大鼠的甲状腺素（T4）水平降低，三碘甲状腺原氨酸（T3）水平升高。然而，这些变化不受白藜芦醇的显著影响。GK 大鼠的血糖水平升高，但白藜芦醇不能改善高血糖症。还表明，糖尿病大鼠的血液肌酐水平升高。然而，在接受白藜芦醇治疗的动物中，血液肌酐水平保持不变。研究表明，胃饥饿素、Spexin 和其他与肾功能间接相关的血液参数的浓度在 GK 和对照组大鼠中相似。这些结果表明，白藜芦醇有益地影响糖尿病大鼠组织中的胆固醇浓度；然而，它对甲状腺激素和葡萄糖无效。此外，还表明白藜芦醇在非糖尿病动物中没有引起任何显著的影响。
