García-González Mario, Muñoz Fernando, González-Cantalapiedra Antonio, López-Peña Mónica, Saulacic Nikola
Department of Veterinary Clinical Sciences, Faculty of Veterinary, University of Santiago de Compostela, 27002 Lugo, Spain.
Department of Cranio-Maxillofacial Surgery, Faculty of Medicine, University of Bern, 3008 Bern, Switzerland.
Animals (Basel). 2020 Dec 9;10(12):2347. doi: 10.3390/ani10122347.
This study is aimed at synthesizing all available evidence on vertical alveolar osteogenesis distraction (VAOD) in animal trials to determine whether the animal model used and its handling influence or not, and find which is the most appropriate animal model for this specific technique. This systematic review has been carried out following the PRISMA statements. Bibliographic sources have been consulted manually by two reviewers. Risk of bias was assessed using a version of the Newcastle-Ottawa-Scale (NOS). The selection criteria established by expert researchers were applied in order to decide which studies should be included in the review. Twenty-six studies met the inclusion criteria and were included in the review. Twenty-four of them had a high quality (score between 7 and 9), two medium quality (score between 4 and 6), and none low quality (score between 1 and 3). The highest possible score was 9 (using the NOS). Six studies complied with all NOS criteria. The animal model has been seen to influence the results, leading to failure in some cases. The most used animal model on VAOD, with fewer complications, was the Mongrel dog. The use of the pig and minipig is not recommended, due to the difficulties in handling and complications encountered.
本研究旨在综合动物试验中关于垂直牙槽骨生成牵张术（VAOD）的所有现有证据，以确定所使用的动物模型及其操作是否产生影响，并找出哪种动物模型最适合该特定技术。本系统评价是按照PRISMA声明进行的。两名评审员手动查阅了文献来源。使用纽卡斯尔-渥太华量表（NOS）的一个版本评估偏倚风险。应用专家研究人员制定的选择标准来决定哪些研究应纳入综述。26项研究符合纳入标准并被纳入综述。其中24项质量高（得分在7至9分之间），2项质量中等（得分在4至6分之间），没有质量低的（得分在1至3分之间）。最高可能得分为9分（使用NOS）。六项研究符合所有NOS标准。已发现动物模型会影响结果，在某些情况下会导致失败。VAOD中使用最多、并发症较少的动物模型是杂种犬。由于操作困难和遇到的并发症，不建议使用猪和小型猪。
