Gulhane Military Medical Academy, Department of Oral and Maxillofacial Surgery, Ankara, Turkey.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Apr;113(4):472-9. doi: 10.1016/j.tripleo.2011.04.012. Epub 2011 Jul 20.
The aim of this study was to evaluate the effects of estrogen deficiency on newly formed bone obtained by osteogenic periosteal distraction histomorphometrically.
Thirty-six female rabbits were divided into 2 groups. The experimental group underwent a bilateral ovariectomy and a sham operation was applied to the control group to equalize the stress of ovariectomy surgery. Four weeks postoperatively, a gradual distraction of the mandibular corpus was performed.
In the experimental group, callus formation was delayed and the new bone was less mineralized; conversely, when histomorphometric measurements were compared statistically, there were no significant differences between the ovariectomized and sham-operated subgroups in the mean extent of newly formed bone tissue.
Although osteoporosis caused by the lack of estrogen has negative effects on osteogenic periosteal distraction (OPD), these negative effects do not appear to present a contraindication to OPD.
本研究旨在通过组织形态计量学评估去势对成骨骨膜牵张新骨形成的影响。
36 只雌性兔分为 2 组。实验组行双侧卵巢切除术，对照组行假手术以平衡卵巢切除术的应激。术后 4 周，行下颌骨体逐渐牵张。
实验组骨痂形成延迟，新骨矿化较少；相反，当进行组织形态计量学测量时，去势组和假手术组之间新生成骨组织的平均程度没有显著差异。
尽管雌激素缺乏引起的骨质疏松对成骨骨膜牵张（OPD）有负面影响，但这些负面影响似乎并不是 OPD 的禁忌症。
