Uzun Necati, Akıncı Mehmet Akif
Necmettin Erbakan University Meram School of Medicine, Department of Child and Adolescent Psychiatry, Konya, Turkey.
Dr. Ali Kemal Belviranlı Maternity and Children Hospital, Department of Child and Adolescent Psychiatry, Konya, Turkey.
Med Hypotheses. 2021 Jan;146:110440. doi: 10.1016/j.mehy.2020.110440. Epub 2020 Nov 29.
In the etiology of anxiety disorders, immune system and inflammation are suggested to play a role. This study hypothesized that there is a relationship between anxiety disorders and inflammation. This retrospective study included 131 children and adolescents between the ages 6-17 who were diagnosed with anxiety disorders. Control group consisted of 131 healthy children with no history of psychiatric disorders or chronic inflammatory conditions. White blood cell (WBC), neutrophil (NEU), lymphocyte, monocyte, basophil, eosinophil values and other hematological markers were noted. From those values, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), and other ratios were calculated. WBC and NEU values were significantly higher in children and adolescents with anxiety disorder compared to the control group. In addition, NLR, MLR and PLR values were significantly higher than the control group. Other measured parameters and calculated values did not differ between study groups. No statistically significant difference was found between Generalized Anxiety Disorder (GAD) group, Social Anxiety Disorder group and Not Otherwise Specified Anxiety Disorders (AD-NOS) group in terms of hematological markers except RDW-CV. Only RDW-CV was found statistically significantly higher in AD-NOS group compared to GAD. These results show that there is an association between inflammation and anxiety disorders. Also, it is postulated that hematological parameters can be used as a useful marker in the follow-up of patients with anxiety disorders.
在焦虑症的病因学中，免疫系统和炎症被认为发挥了作用。本研究假设焦虑症与炎症之间存在关联。这项回顾性研究纳入了131名年龄在6至17岁之间被诊断为焦虑症的儿童和青少年。对照组由131名无精神疾病或慢性炎症病史的健康儿童组成。记录了白细胞（WBC）、中性粒细胞（NEU）、淋巴细胞、单核细胞、嗜碱性粒细胞、嗜酸性粒细胞值以及其他血液学指标。根据这些值，计算中性粒细胞/淋巴细胞比值（NLR）、血小板/淋巴细胞比值（PLR）、单核细胞/淋巴细胞比值（MLR）以及其他比值。与对照组相比，焦虑症儿童和青少年的WBC和NEU值显著更高。此外，NLR、MLR和PLR值也显著高于对照组。研究组之间其他测量参数和计算值没有差异。除红细胞分布宽度变异系数（RDW-CV）外，广泛性焦虑障碍（GAD）组、社交焦虑障碍组和未特定的焦虑症（AD-NOS）组在血液学指标方面没有统计学显著差异。仅发现AD-NOS组的RDW-CV在统计学上显著高于GAD组。这些结果表明炎症与焦虑症之间存在关联。此外，推测血液学参数可作为焦虑症患者随访中的有用标志物。
